211676-01-6

Basic information

• Product Name: Benzenesulfonamide, N-methyl-N-(3-methylphenyl)-4-nitro-
• CAS NO: 211676-01-6
• Molecular Formula: C14H14N2O4S
• Molecular Weight: 306.342
• Mol File: 211676-01-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-methyl-N-(3-methylphenyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-methyl-N-(3-methylphenyl)-4-nitro-(211676-01-6)
• EPA Substance Registry System: Benzenesulfonamide, N-methyl-N-(3-methylphenyl)-4-nitro-(211676-01-6)

Safety Data

• Hazardous Substances Data: 211676-01-6(Hazardous Substances Data)

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 108-44-1 1-amino-3-methylbenzene 
• 186581-53-3 diazomethane 
• 16936-94-0 4-nitro-N-(m-tolyl)benzenesulfonamide 
• 6319-45-5 N-methyl-4-nitro-benzenesulfonamide 
• 108-88-3 toluene 

Downstream Products

• 3406-75-5 2-(4-nitrophenylthio)acetic acid 
• 696-44-6 N-methyl-m-toluidine 

Relevant articles and documents

Highly specific N-monomethylation of primary aromatic amines

A synthetic methodology for the specific conversion of primary aromatic amines into their N-monomethyl derivatives under very mild conditions is presented. Anilines are treated with 4-nitrobenzenesulfonyl (nosyl) chloride to generate the corresponding sulfonamides 2 in high yields. The subsequent N-methylation reaction of the sulfonamides 2 with a solution of diazomethane is rapid and quantitative. Removal of the nosyl protecting group is readily carried out using the reagent system mercaptoacetic acid/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) affording the N-monomethylated aromatic amines 4. The procedure is convenient, efficient, and gives rise to the N-monomethyl-anilines exclusively.