211749-07-4Relevant articles and documents
Synthesis of novel flavonoid derivatives as potential HIV-integrase inhibitors
Mateeva, Nelly N.,Kode, Rao N.,Redda, Kinfe K.
, p. 1251 - 1258 (2007/10/03)
Eighteen novel flavonoid derivatives - substituted chalcones and flavones were synthesized and characterized by using NMR, IR, UV/Vis spectroscopy and elemental analysis. The target compounds were achieved by using a sequence of simple and effective reactions starting from phloroglucinol. The initial hydroxyl groups were protected by methylation and in the final flavones the 5-OH group was selectively demethylated by means of AlBr3. 5-methoxy flavones exhibit a strong fluorescence, which was quenched after the removal of the methyl group.