21303-50-4

Basic information

• Product Name: 5-Methyl-2-mercaptobenzothiazole
• Synonyms: 2-Mercapto-5-methyl bezimidazole;2(3H)-Benzothiazolethione,5-methyl-(9CI);5-Methyl-2-mercaptobenzothiazole;5-Methyl-2(3H)-benzothiazolethione;5-Methyl-2-benzothiazolethiol;5-Methylbenzo[d]thiazole-2-thiol;5-methyl-3H-1,3-benzothiazole-2-thione
• CAS NO: 21303-50-4
• Molecular Formula: C₈H₇NS₂
• Molecular Weight: 181.28
• Product Categories: BENZOTHIAZOLE;Heterocycles;Heterocyclic Compound
• Mol File: 21303-50-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 121 °C
• Boiling Point: 314 °C
• Flash Point: 144 °C
• Appearance: /
• Density: 1.39
• Vapor Pressure: 0.000464mmHg at 25°C
• Refractive Index: 1.743
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.60±0.20(Predicted)
• CAS DataBase Reference: 5-Methyl-2-mercaptobenzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-2-mercaptobenzothiazole(21303-50-4)
• EPA Substance Registry System: 5-Methyl-2-mercaptobenzothiazole(21303-50-4)

Safety Data

• Hazardous Substances Data: 21303-50-4(Hazardous Substances Data)

Usage

General Description

5-Methyl-2-mercaptobenzothiazole is a chemical compound that is commonly used as an additive in industrial processes, particularly in the production of rubber. It is known for its ability to inhibit the growth of bacteria and fungi, and is often used as a biocide in industrial water systems. Additionally, it has applications as a corrosion inhibitor in the oil and gas industry. 5-Methyl-2-mercaptobenzothiazole is also used in the manufacturing of pesticides, and has been found to have some potential for use in pharmaceuticals. However,

InChI:InChI=1/C8H7NS2/c1-5-2-3-7-6(4-5)9-8(10)11-7/h2-4H,1H3,(H,9,10)

Upstream product

• 53078-85-6 2-bromo-5-methylaniline 
• 140-89-6 potassium ethyl xanthogenate 
• 75-15-0 carbon disulfide 
• 638-03-9 m-toluidine hydrochloride 
• 13194-69-9 2-iodo-5-methylaniline 
• 108-44-1 1-amino-3-methylbenzene 
• 95-81-8 2-chloro-5-methylaniline 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 
• 452-84-6 3-amino-4-fluorotoluene 

Downstream Products

• 3622-48-8 5-methyl-2-methylsulfanyl-1,3-benzothiazole 
• 80945-66-0 (5-methyl-1,3-benzothiazol-2-yl)hydrazine 
• 315228-94-5 1-[3-Chloro-2-(5-methyl-benzothiazol-2-ylsulfanyl)-5-nitro-phenyl]-ethanone 
• 2942-16-7 5-methylbenzo[d]thiazole 
• 3622-31-9 2-chloro-5-methylbenzo[d]thiazole 
• 14779-17-0 2-amino-5-methylbenzothiazole 

Relevant articles and documents

Thiazolyl and benzothiazolyl hydrazones derived from α-(N)-acetylpyridines and diazines: Synthesis, antiproliferative activity and CoMFA studies

The synthesis of a series of thiazolyl and benzothiazolyl hydrazones derived from α-(A3-acylpyridines, -quinolines, -isoquinolines, -pyridazines, -pyrimidines, and -pyrazines is reported. The stereochemistry of these compounds was determined by NMR spectroscopic methods. The antiproliferative activity of the novel compounds was quantified in tissue culture (melanoma, breast carcinoma, colon adenocarcinoma, epitheloid cervix carcinoma, Burkitt's lymphoma, leukemia, and hydroxyurea sensitive and resistant myelogenous leukemia sublines). All compounds exhibited profound antiproliferative activity, in particular against Burkitt's lymphoma cells. Out of this series, compounds 6b, 7b, 7c, 8c and 8i were found to be 13-900 times more potent than hydroxyurea and no cross-resistance to hydroxyurea was observed. A predictive 3D-QSAR model using the CoMFA approach was established.

Synthesis and evaluation of some benzothiazole derivatives as antidiabetic agents

Objective: The objective of the present research investigation involves synthesis and biological evaluation of antidiabetic activity of benzothiazole derivatives. Methods: A novel series of benzothiazole derivatives 7(a-l) were synthesised and synthesised compounds were characterised for different physical and chemical properties like molecular formula, molecular weight, melting point, percentage yield, Rf value, IR,1HNMR,13CNMR and mass spectroscopy. The newly synthesised benzothiazole derivatives were subsequently assayed in vivo to investigate their hypoglycemic activity by the alloxan-induced diabetic model in rats. Results: All the synthesised derivatives showed significant biological efficacy. The compound 7d at 350 mg/kg exerted maximum glucose lowering effects whereas 7c showed minimum glucose lowering effects. All the compounds were effective, and experimental results were statistically significant at p0.01 and p0.05 level. Conclusion: From the results, it is clear that compound 7d demonstrated potent anti-diabetic activity and would be of better use in drug development to combat the metabolic disorder in future.

COMPOUNDS FOR MODULATING TRPV3 FUNCTION

The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.