452-84-6

Basic information

• Product Name: 2-Fluoro-5-methylaniline
• Synonyms: Benzenamine, 2-fluoro-5-methyl-;2-FLUORO-5-METHYLANILINE;6-FLUORO-M-TOLUIDINE;3-AMINO-4-FLUOROTOLUENE;2-Fluoro-5-methylbenzeneamine ;3-Amino-4-fluorotoluene~6-Fluoro-m-toluidine;2-Fluoro-5-methylbenzenamine;2-Fluoro-5-methylaniline,99%
• CAS NO: 452-84-6
• Molecular Formula: C₇H₈FN
• Molecular Weight: 125.14
• Product Categories: Fluorin-contained toluene series;Anilines, Aromatic Amines and Nitro Compounds;Aniline;Aniline series
• Mol File: 452-84-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 80-86 °C11 mm Hg(lit.)
• Flash Point: 179 °F
• Appearance: Clear yellow to brown/Liquid
• Density: 1.109 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.307mmHg at 25°C
• Refractive Index: n20/D 1.533(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.33±0.10(Predicted)
• BRN: 2715995
• CAS DataBase Reference: 2-Fluoro-5-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-methylaniline(452-84-6)
• EPA Substance Registry System: 2-Fluoro-5-methylaniline(452-84-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-23/24/25
• Safety Statements: 26-36-45-2636/37/39-36/37/39-27
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 452-84-6(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to brown liquid

InChI:InChI=1/C7H8FN/c1-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3

Upstream product

• 442-10-4 1-(2-fluoro-5-methyl-phenyl)-propan-1-one oxime 
• 1403336-96-8 1-(4-chlorophenyl)-2-(m-tolyl)diazene 
• 588-04-5 3,3'-dimethylazobenzene 
• 446-11-7 4-fluoro-3-nitrotoluene 
• 452-62-0 3-bromo-4-fluorotoluene 

Downstream Products

• 106976-08-3 2-(2-Fluoro-5-methyl-phenylamino)-3-nitro-benzoic acid 
• 21303-50-4 5-methylbenzo[d]thiazole-2(3H)-thione 
• 712338-99-3 N-(2-fluoro-5-methylphenyl)-4-methylbenzenesulfonamide 
• 885399-05-3 N-(5-fluoro-2-methylphenyl)methanesulfonamide 
• 446-11-7 4-fluoro-3-nitrotoluene 
• 418762-26-2 4-bromo-2-fluoro-5-methylaniline 
• 630119-82-3 2-chloro-N-(2-fluoro-5-methylphenyl)acetamide 
• 1262762-02-6 2-[(2-fluoro-5-methyl-phenyl)-methyl-amino]-2-prop-2-ynyl-malonic acid diethyl ester 
• 1242606-85-4 C₂₇H₂₇FN₆O 
• 1571111-65-3 N-(2-fluoro-5-methylphenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthalenecarboxamide 
• 1571111-43-7 6-(3-amino-1H-indazol-4-yl)-N-(2-fluoro-5-methylphenyl)-1-naphthalenecarboxamide 

Relevant articles and documents

-

-

Synthesis of 2 - fluoro aniline compounds of the method

The invention discloses a method for synthesizing 2 - fluoro aniline compounds of the method, the method is: shown in formula Ia aniline compound of formula Ib α and β shown aniline compound as raw materials, through coupling reaction shown [...] azobenzene compound II, then the type II shown azobenzene compound with a palladium catalyst, fluorination reagent, additive, organic solvent, in the 30 - 150 °C temperature closed agitating the fluorination reaction, [...] compound of formula III, type III compounds are shown in the reaction under the action of a reducing [...] shown IV 2 - fluoro aniline compounds; this invention synthetic 2 - fluoro aniline compounds substrate wide adaptability, mild reaction conditions, the operation is simple, fluorinated and good selectivity, [...] aniline compounds is prepared by many drug molecule is an important intermediate and starting material, wide application prospects.

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed