21353-89-9

Basic information

• Product Name: N-methyl-N-(3-nitrophenyl)acetamide
• Synonyms: N-methyl-N-(3-nitrophenyl)acetamide;3'-Nitro-N-methylacetoanilide;N-(3-Nitrophenyl)-N-methylacetamide;N-Methyl-3'-nitroacetanilide
• CAS NO: 21353-89-9
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.19
• Mol File: 21353-89-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 99-101°
• Boiling Point: 321.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.270±0.06 g/cm3(Predicted)
• PKA: -1.93±0.50(Predicted)
• CAS DataBase Reference: N-methyl-N-(3-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(3-nitrophenyl)acetamide(21353-89-9)
• EPA Substance Registry System: N-methyl-N-(3-nitrophenyl)acetamide(21353-89-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 21353-89-9(Hazardous Substances Data)

Usage

General Description

N-methyl-N-(3-nitrophenyl)acetamide is an organic compound with the molecular formula C9H10N2O3. It is a white to light yellow crystalline powder that is soluble in organic solvents and sparingly soluble in water. This chemical is used in organic synthesis as a reagent for the preparation of various compounds, including pharmaceuticals and agrochemicals. It is also used as an intermediate in the manufacturing of dyes and pigments. N-methyl-N-(3-nitrophenyl)acetamide is classified as an irritant and should be handled with care to avoid contact with skin, eyes, and mucous membranes.

Upstream product

• 619-26-1 N-methyl-3-nitroaniline 
• 75-36-5 acetyl chloride 
• 619-31-8 N,N-dimethyl-3-nitroaniline 
• 108-24-7 acetic anhydride 
• 122-28-1 N-(3-nitrophenyl)acetanilide 
• 74-88-4 methyl iodide 

Downstream Products

• 848678-68-2 4-amino-1-methyl-1,3-dihydro-2H-indol-2-one 
• 61679-27-4 N-(3-aminophenyl)-N-methyl-acetamide 
• 71-50-1 acetate 
• 619-26-1 N-methyl-3-nitroaniline 

Relevant articles and documents

Amide Bond Formation Catalyzed by Recyclable Copper Nanoparticles Supported on Zeolite Y under Mild Conditions

A series of catalysts based on supported copper nanoparticles have been prepared and tested in the amide bond formation from tertiary amines and acid anhydrides, in the presence of tert-butyl hydroperoxide as an oxidant. Copper nanoparticles on zeolite Y (CuNPs/ZY) was found to be the most efficient catalyst for the synthesis of amides, working in acetonitrile as solvent, under ligand- and base-free conditions in air. The products were obtained in good to excellent yields and in short reaction times. The CuNPs/ZY system also exhibited higher catalytic activity than some commercially available copper and iron sources and it was reused in ten reaction cycles without any further pre-treatment. This methodology has been successfully scaled-up to a gram scale with no detriment to the yield.

PURINE DERIVATIVES

Purine derivatives of Formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors.

Metasubstituted thiazolidinones, their manufacture and use as a drug

This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.