- Amide Bond Formation Catalyzed by Recyclable Copper Nanoparticles Supported on Zeolite Y under Mild Conditions
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A series of catalysts based on supported copper nanoparticles have been prepared and tested in the amide bond formation from tertiary amines and acid anhydrides, in the presence of tert-butyl hydroperoxide as an oxidant. Copper nanoparticles on zeolite Y (CuNPs/ZY) was found to be the most efficient catalyst for the synthesis of amides, working in acetonitrile as solvent, under ligand- and base-free conditions in air. The products were obtained in good to excellent yields and in short reaction times. The CuNPs/ZY system also exhibited higher catalytic activity than some commercially available copper and iron sources and it was reused in ten reaction cycles without any further pre-treatment. This methodology has been successfully scaled-up to a gram scale with no detriment to the yield.
- Moglie, Yanina,Buxaderas, Eduardo,Mancini, Agustina,Alonso, Francisco,Radivoy, Gabriel
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p. 1487 - 1494
(2019/02/16)
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- SELECTIVE KINASE INHIBITORS
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Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
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Paragraph 0522; 0523; 0549; 0550
(2013/06/06)
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- PURINE DERIVATIVES
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Purine derivatives of Formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors.
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Page/Page column 69-70
(2008/12/07)
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- PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS
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Pyrrolopyrimidine derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors.
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Page/Page column 67-68
(2008/12/04)
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- Metasubstituted thiazolidinones, their manufacture and use as a drug
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This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.
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Page/Page column 43
(2010/11/25)
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- Amide conformational switching induced by protonation of aromatic substituent
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(Matrix presented) Introduction of an electron-withdrawing group on the aromatic ring of N-methylacetanilide decreased the ratio of the cis conformer, and the ratio correlates well with the Hammett σ values of the substituents. These steric properties can be applied to achieve amide conformational swiching by protonation at the aromatic substituent of 4-[bis(dimethylamino)]-N-methylacetanilide or N-[p-(dimethylamino)phenyl]-N-phenylacetamide.
- Yamasaki, Ryu,Tanatani, Aya,Azumaya, Isao,Saito, Shoichi,Yamaguchi, Kentaro,Kagechika, Hiroyuki
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p. 1265 - 1267
(2007/10/03)
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- Spectral and Electrooptical Properties of Ring Substituted N-methyl-N-phenylnitramines
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Secondary aromatic nitramines absorb in IR at 1517-1536, 1285-1299 and 755-759 cm-1 irrespective of the nature of an aromatic ring.Comparison of the 1H and 13C NMR spectra of ring substituted N-methyl-N-phenylnitrmines indicate that interaction between the substituents is poorly transmitted across the ring. α-Cleavage observed in the mass spectra of nitramines shows that the Ar-N bond is abnormally weak.Dipole moments of N-methyl-N-phenylnitrmines find a simple explanation assuming that the unshared electron pair is shifted towards the aromatic ring only in the presence of electron demanding substituents in conjugated position.The results are incompatible with the solvent-caged-pair theory of the nitramine rearrangement. - Key words: secondary nitramines; NMR; IR; mass spectra; dipole moments; Kerr constants
- Daszkiewicz, Z.,Nowakowska, E.,Prezdo, W. W.,Kyziol, J. B.
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p. 1437 - 1446
(2007/10/03)
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