213771-38-1Relevant articles and documents
Synthesis of 5-bromopyridyl-2-magnesium chloride and its application in the synthesis of functionalized pyridines
Song, Jinhua J.,Yee, Nathan K.,Tan, Zhulin,Xu, Jinghua,Kapadia, Suresh R.,Senanayake, Chris H.
, p. 4905 - 4907 (2007/10/03)
(Chemical Equation Presented) The 5-bromopyridyl-2-magnesium chloride (2), which was not accessible previously, was efficiently synthesized for the first time via an iodomagnesium exchange reaction with 5-bromo-2-iodopyridine (1). This reactive intermediate was allowed to react with a variety of electrophiles to afford a range of useful functionalized pyridine derivatives. Application of this methodology to 5-bromo-2-iodo-3-picoline provided a simple and economical synthesis of a key intermediate for the preparation of Lonafarnib, a potent anticancer agent.
Novel 2,2-bipyridine ligand for palladium-catalyzed regioselective carbonylation
Wu, George Guangzhong,Wong, YeeShing,Poirier, Marc
, p. 745 - 747 (2008/02/12)
Formula presented A palladium-catalyzed highly regioselective one-step carbonylation of 2,5-dibromo-3-methylpyridine is reported. A range of alkyl esters and amides can be prepared in good yield with better than 95:5 regioselectivity via this method. Key