376587-52-9

Basic information

• Product Name: 5-Bromo-2-iodo-3-methylpyridine
• Synonyms: 5-BROMO-2-IODO-3-METHYLPYRIDINE;5-bromo-2-indo-methylpyridine
• CAS NO: 376587-52-9
• Molecular Formula: C6H5BrIN
• Molecular Weight: 297.92
• EINECS: 205-525-8
• Product Categories: pharmacetical
• Mol File: 376587-52-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 279.859 °C at 760 mmHg
• Flash Point: 123.054 °C
• Appearance: /
• Density: 2.172 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.22±0.20(Predicted)
• CAS DataBase Reference: 5-Bromo-2-iodo-3-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-iodo-3-methylpyridine(376587-52-9)
• EPA Substance Registry System: 5-Bromo-2-iodo-3-methylpyridine(376587-52-9)

Safety Data

• Hazardous Substances Data: 376587-52-9(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-iodo-3-methylpyridine is a chemical compound with the molecular formula C6H5BrIN2. It is a derivative of pyridine with bromine and iodine substituents at the 5 and 2 positions, respectively, and a methyl group at the 3 position. 5-Bromo-2-iodo-3-methylpyridine is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has a wide range of applications in the field of medicinal chemistry and chemical research. The presence of both bromine and iodine atoms makes 5-Bromo-2-iodo-3-methylpyridine a valuable reagent for various chemical reactions and transformations, making it an important compound in the field of organic synthesis.

InChI:InChI=1/C6H5BrIN/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3

Upstream product

• 3430-18-0 2,5-dibromo-3-methylpyridine 

Downstream Products

• 213771-38-1 3-methyl-5-bromopyridine-2-N-phenylamide 
• 376587-53-0 5-bromo-3-methylpyridine-2-carbaldehyde 
• 1010422-52-2 5-bromo-3-methyl-2-(trifluoromethyl)pyridine 
• 1575836-59-7 tert-butyl 3'-bromo-1H,5'H-spiro[azetidine-3,7'-furo[3,4-b]pyridine]-1-carboxylate 
• 1359945-14-4 5′-bromo-3′,5-dimethyl-6-(2-methyl-4-pyridin-3-ylphenyl)-3,2′-bipyridine 
• 1253279-49-0 5-bromo-2-(4-bromo-3-methylphenyl)-3-methylpyridine 

Relevant articles and documents

Mechano-Sensitive Synthetic Ion Channels

Mechanical stress is a ubiquitous stimulus sensed by membrane proteins, but rarely by synthetic molecules. Inspired by mechano-sensitive ion channels found in cell membranes, tension-responsive transmembrane multiblock amphiphiles were developed. In membranes, a single-transmembrane amphiphile responds to both expanding and contracting tensions to weaken and strengthen the stacking of membrane-spanning units, respectively, and ion transportation is triggered by expanding tension to form a supramolecular channel, while little transportation is observed under a tensionless condition. In contrast, a three-transmembrane amphiphile showed little spectroscopic response to tensions, likely due to weaker stacking of membrane-spanning units than in the single-transmembrane amphiphile. Nevertheless, the three-transmembrane amphiphile shows ion transportation by forming a unimolecular channel even under a tensionless condition, and the ion-transporting activity decreased with expanding tension. Interestingly, the estimated operating force of these synthetic systems was comparable to that of the mechano-sensitive proteins. This study opens the door toward new mechano-sensitive molecular devices.

PHARMACEUTICALS COMPRISING BIARYL DERIVATIVES OR SALTS THEREOF

PROBLEM TO BE SOLVED: To provide compounds with excellent antimycotic activity against Trichophyton. SOLUTION: The invention provides pharmaceuticals comprising biaryl derivatives represented by general formula (I) or salts thereof, where ring A is optionally substituted phenyl or the like; Q is CH2 or the like; X1, X2 and X3 are CR1 or the like; and Y is CH or N. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

SPIROCYCLIC ISOXAZOLINES AS ANTIPARASITIC AGENTS

The invention recites spirocyclic isoxazoline derivatives of Formula (1) stereoisomers thereof, veterinary or pharmaceutical acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables