214353-17-0

Basic information

• Product Name: 2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone
• Synonyms: 2-TRIFLUOROACETYL-4-CHLORO ANILINE;2'-AMINO-5'-CHLORO-2,2,2-TRIFLUOROACETOPHENONE;2-AMINO-5-CHLORO-2',2',2'-TRIFLUOROACETOPHENONE;1,1-ETHANEDIOL, 1-(2-AMINO-5-CHLOROPHENYL)-2,2,2-TRIFLUORO-, HYDROCHLORIDE;2-Amino-5-chlorophenyl-2,2,2-trifluoroethanone;4-Chloro-2-trifluoroacetoaniline hydrochloride hydrate;2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone hydrochloride ,98%;Efavirinz intermediate
• CAS NO: 214353-17-0
• Molecular Formula: C8H5ClF3NO
• Molecular Weight: 223.58
• Mol File: 214353-17-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone(214353-17-0)
• EPA Substance Registry System: 2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone(214353-17-0)

Safety Data

• Hazardous Substances Data: 214353-17-0(Hazardous Substances Data)

Usage

General Description

2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone is a synthetic organic compound with the molecular formula C8H6ClF3NO. It is a derivative of acetophenone with a chlorine and trifluoromethyl group attached to the phenyl ring. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has also been studied for its potential use in medicinal chemistry, particularly for its antibacterial and antifungal properties. Additionally, it is used as a building block in the synthesis of complex organic molecules.

Upstream product

• 354-32-5 trifluoracetyl chloride 
• 65854-91-3 N-(4-chlorophenyl)-2,2-dimethylpropionamide 
• 29551-81-3 N-chloro-N-(2-chlorophenyl)acetamide 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 1150561-03-7 N-[2-(trifluoroacetyl)phenyl]-2,2-dimethylpropionamide 
• 62662-74-2 N-(2-chlorophenyl)-2,2,2-trimethylacetamide 
• 95-51-2 o-chloroaniline 
• 430458-62-1 N-(2-bromophenyl)isobutyramide 
• 6625-74-7 N-pivaloylaniline 
• 62-53-3 aniline 
• 181190-33-0 N-(4-chloro-2-(2,2,2-trifluoroacetyl)phenyl)pivalamide 
• 106-47-8 4-chloro-aniline 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 209460-09-3 1-[5-chloro-2-(tritylamino)phenyl]-2,2,2-trifluoroethan-1-one 

Relevant articles and documents

Practical asymmetric synthesis of Efavirenz (DMP 266), an HIV-1 reverse transcriptase inhibitor

A highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described. The synthesis proceeds in 62% overall yield in seven steps from 4-chloroaniline (6) to give efavirenz (1) in excellent chemical and optical purity. A novel, enantioselective addition of Li-cyclopropyl acetylide (4a) to p-methoxybenzyl-protected ketoaniline 3a mediated by (1R,2S)-N-pyrrolidinylnorephedrine lithium alkoxide (5a) establishes the stereogenic center in the target with a remarkable level of stereocontrol.

A preparing method of an efavirenz intermediate

The invention provides a preparing method of an efavirenz intermediate, and relates to the technical field of compound preparation methods. The method includes performing amino protection on 2-halogenaniline (II), as a raw material, with acyl chloride; reacting the generated N-acyl-2-halogen-aniline (III) with metal magnesium to generate a Grignard reagent; then reacting the Grignard reagent witha trifluoroacetyl amine compound (IV) to obtain N-acyl-2-(trifluoroacetyl)aniline (V); then reacting the N-acyl-2-(trifluoroacetyl)aniline (V) with chlorine under the function of a catalyst to obtainN-acyl-4-chloro-2-(trifluoroacetyl)aniline (VI); and performing hydrolysis and salting to obtain 4-chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate (I). The method has characteristics of shortsynthetic steps, simple operation, high safety, a large raw material choosing range, and a high yield of the target product, and is suitable for large-scale industrial production.

Preparation method of 4-chloro-2-(trifluoroacetyl) aniline hydrochloride hydrate

The invention discloses a preparation method of a 4-chloro-2-(trifluoroacetyl) aniline hydrochloride hydrate and belongs to the field of compound synthesis. The method adopts parachloroaniline as a raw material and comprises steps as follows: 1, parachlor