214420-92-5

Basic information

• Product Name: 2-(4-nitro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole
• Synonyms: 2-(4-nitro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole
• CAS NO: 214420-92-5
• Molecular Weight: 232.239
• Mol File: 214420-92-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-nitro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole(214420-92-5)
• EPA Substance Registry System: 2-(4-nitro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole(214420-92-5)

Safety Data

• Hazardous Substances Data: 214420-92-5(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 39098-01-6 N-(2-methylbut-3-yn-2-yl)-4-nitrobenzamide 

Relevant articles and documents

Silver-catalyzed preparation of oxazolines from N-propargylamides

Treatment of N-propargylamides with 5 mol% of silver hexafluoroantimonate results in the rapid formation of oxazolines in essentially quantitative yield. Georg Thieme Verlag Stuttgart.

Process to chloroketones using oxazolines

This invention relates to a process for the preparation of an α-chloroketone compound comprising the steps of (i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline STR1 (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate STR2 and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone STR3 wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene, R is a hydrogen atom or alkyl, and R1 and R2 are each independently an alkyl or substituted alkyl group, or R1 and R2 together with the carbon atom to which they are attached form a cyclic structure. Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.

Process for the preparation of chloroketones using oxazolines

This invention relates to a process for the preparation of an α-chloroketone compound comprising the steps of (i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene, R is a hydrogen atom or alkyl, and R1and R2are each independently an alkyl or substituted alkyl group, or R1and R2together with the carbon atom to which they are attached form a cyclic structure. Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.