214485-08-2

Basic information

• Product Name: 3-Quinolinecarbonitrile, 6-amino-4-[(3-chloro-4-fluorophenyl)amino]-
• CAS NO: 214485-08-2
• Molecular Formula: C16H10ClFN4
• Molecular Weight: 312.734
• Mol File: 214485-08-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarbonitrile, 6-amino-4-[(3-chloro-4-fluorophenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 6-amino-4-[(3-chloro-4-fluorophenyl)amino]-(214485-08-2)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 6-amino-4-[(3-chloro-4-fluorophenyl)amino]-(214485-08-2)

Safety Data

• Hazardous Substances Data: 214485-08-2(Hazardous Substances Data)

Upstream product

• 2458-24-4 2-cyano-3-(4-nitro-phenylamino)-acrylic acid ethyl ester 
• 214470-35-6 6-nitro-4-oxo-1,4-dihydro-quinoline-3-carbonitrile 
• 214485-09-3 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-quinoline-3-carbonitrile 
• 57338-24-6 (E)-ethyl 2-cyano-3-((4-nitrophenyl)amino)acrylate 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 214470-37-8 4-chloro-6-nitro-3-quinolinecarbonitrile 
• 100-01-6 4-nitro-aniline 
• 2305-65-9 4-hydroxy-6-nitroquinoline-3-carbonitrile 
• 57338-20-2 2-Cyano-3-(4-nitro-phenylamino)-acrylic acid ethyl ester 

Downstream Products

• 214485-41-3 N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(Z)-2-butenamide 
• 214485-42-4 N-{4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl}-4-methoxy-(Z)-2-butenamide 
• 214485-51-5 N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl}-4-methoxy-2-butynamide 
• 214485-50-4 N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-2-butynamide 
• 214485-04-8 N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl]-4-dimethylamino-(z)-2-butenamide 
• 214485-05-9 N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl}-4-diethylamino-2-butenamide 
• 214485-06-0 N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl}-4-morpholino-2-butenamide 
• 915360-45-1 6-(3-amino-benzylamino)-4-(3-chloro-4-fluoro-phenylamino)-quinoline-3-carbonitrile 

Relevant articles and documents

Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors

This invention provides compounds of formula 1 wherein R1, G1, G2, R4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof, which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.

Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis

The synthesis and structure-activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described. Potent inhibitors of Tpl2 kinase with selectivity against a panel of selected kinases in enzymatic assays and specificity in cell-based phosphorylation assays in LPS-treated human monocytes were identified. Selected inhibitors with moderate activity in human whole blood assay effectively inhibited LPS/D-Gal induced TNFα release when administered intraperitoneally in mice.

USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS

This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula (1); wherein R1, R2, R3, R4, X, Y, and n are defined hereinbefore, or a pharmaceutically acceptable salt thereof.