2149-49-7

Basic information

• Product Name: phenyl 2-oxopropanoate
• Synonyms: Phenyl pyruvate; propanoic acid, 2-oxo-, phenyl ester; Pyruvic acid, phenyl ester
• CAS NO: 2149-49-7
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.158
• Mol File: 2149-49-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 243.1°C at 760 mmHg
• Flash Point: 103.9°C
• Density: 1.166g/cm³
• Vapor Pressure: 0.0326mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: phenyl 2-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 2-oxopropanoate(2149-49-7)
• EPA Substance Registry System: phenyl 2-oxopropanoate(2149-49-7)

Safety Data

• Hazardous Substances Data: 2149-49-7(Hazardous Substances Data)

Upstream product

• 618-32-6 Benzoyl bromide 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 
• 127-17-3 2-oxo-propionic acid 
• 108-95-2 phenol 

Downstream Products

• 122-78-1 phenylacetaldehyde 
• 36065-27-7 N-α-phenylethylacetamide 
• 1224699-71-1 (S)-phenyl 2-hydroxy-2-methyl-4-oxopentanoate 
• 7292-85-5 (2R)-Phenyllactat 
• 86577-51-7 phenyl threo-2,3-dimethyl-2-hydroxy-4-pentenoate 
• 86577-51-7 phenyl erythro-2,3-dimethyl-2-hydroxy-4-pentenoate 
• 100701-86-8 phenyl threo-2,3-dimethyl-2-hydroxy-5-(trimethylsilyl)-4-pentynoate 
• 100701-86-8 phenyl erythro-2,3-dimethyl-2-hydroxy-5-(trimethylsilyl)-4-pentynoate 

Relevant articles and documents

On the mechanism of chorismate mutases: Revisiting structural requirements for catalysis

The behavior of nor-chorismic acid 7 has now been tested against three different chorismate mutases. Notably, 7 is not a substrate for Bacillus subtilis mutase, but is a weak competitive inhibitor (K(I) = 0.5 mM).

Metal-Free Synthesis of Polysubstituted Imidazolinone Through Cyclization of Amidines with 2-Substituted Acrylates

Polysubstituted imidazolinones were synthesized in a facile metal-free cascade nucleophilic cyclization of easily available amidines and 2-substituted acrylates. This protocol is distinguished by simple, mild, and catalyst-free reaction conditions with a broad substrate scope, affording the desired products in moderate to good yields and providing an efficient strategy for synthesis of polysubstituted imidazolinone.

H8-BINOL chiral imidodiphosphoric acids catalyzed enantioselective synthesis of dihydroindolo-/-pyrrolo[1,2- a ]quinoxalines

The first enantioselective synthesis of 5,6-dihydroindolo[1,2-a]quinoxalines is achieved by using a newly developed H8-BINOL-type imidodiphosphoric acid catalyst with low catalyst loading through efficient Pictet-Spengler-type reactions of indolyl anilines with ketones. This methodology also generates phenyl-4,5-dihydropyrrolo[1,2-a]quinoxalines with high yields and excellent enantioselectivities. Moreover, this method was utilized to synthesize an HIV-1 inhibitor with high yield and good enantioselectivity through a one-step procedure.