215124-03-1

Basic information

• Product Name: AKOS B028995
• Synonyms: 5-Chloro-2-hydroxy-3-iodobenzaldehyde 97%;CHEMBRDG-BB 6448206;AKOS B028995;5-CHLORO-2-HYDROXY-3-IODOBENZALDEHYDE;5-chloro-2-hydroxy-3-iodobenzaldehyde(SALTDATA: FREE);5-Chloro-3-iodo-2-hydroxybenzaldehyde;5-Chloro-3-iodosalicylaldehyde
• CAS NO: 215124-03-1
• Molecular Formula: C₇H₄ClIO₂
• Molecular Weight: 282.46
• Mol File: 215124-03-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 87-92°C
• Boiling Point: 245.9°C at 760 mmHg
• Flash Point: 102.5°C
• Appearance: /
• Density: 2.114g/cm³
• Vapor Pressure: 0.0179mmHg at 25°C
• Refractive Index: 1.718
• CAS DataBase Reference: AKOS B028995(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS B028995(215124-03-1)
• EPA Substance Registry System: AKOS B028995(215124-03-1)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 215124-03-1(Hazardous Substances Data)

Usage

General Description

AKOS B028995 is a chemical compound with the molecular formula C16H23NO2. It is commonly known as methoxyacetyl fentanyl, a potent opioid analgesic drug that acts as an agonist at the μ-opioid receptor. It is a synthetic analogue of fentanyl but with a methoxy group attached to the piperidine ring, giving it a slightly different pharmacological profile. The compound is highly potent and has been associated with a number of overdose deaths and adverse effects. AKOS B028995 is a controlled substance in many countries and is strictly regulated due to its potential for abuse and potential health risks.

InChI:InChI=1/C7H4ClIO2/c8-5-1-4(3-10)7(11)6(9)2-5/h1-3,11H

Upstream product

• 635-93-8 5-chlorosalicyclaldehyde 
• 71643-66-8 4-chloro-2-iodo phenol 

Downstream Products

• 243136-10-9 2-O-(MEM)-3-iodo-5-chlorosalicylaldehyde 
• 1048992-87-5 1,1-dimethylethyl 2-[(5-chloro-2-hydroxy-3-iodophenyl)methyl]hydrazinecarboxylate 
• 91-64-5 coumarin 

Relevant articles and documents

A Novel Synthesis of 2-Ferrocenoyl-Substituted Iodobenzofurans

In the present investigation, the first construction of a series of structurally new 2-ferrocenoyl-substituted iodobenzofurans hybrids has been achieved through a simple and mild two-step procedure, involving the iodination of salicylaldehydes using N-iodosuccinimide reagent in eco-friendly PEG-400 medium at room temperature followed by one-pot Rap–Stoermer reaction with 1-chloroacetylferrocene in refluxing MeCN with the presence of K2CO3as base and PEG-400 as the activated additive. These newly synthesized compounds belong to a new class of ferrocene-benzofuran hybrids and could be good candidates for the development of compounds for use in medicinal chemistry.

A simple and efficient method for solvent-free iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid by grinding method

Green, mild and efficient iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid in the solid-state by grinding under solvent-free conditions at room temperature. This method provides several advantages such as environmentally friendly, short reaction times, high yields, non-hazardous and simple work-up procedure.

Pyridinium lodochloride: An efficient reagent for lodination of hydroxylated aromatic ketones and aldehydes

Direct iodination of several reactive aromatic compounds like hydroxy substituted acetophenones and aldehydes with pyridinium iodochloride (PyICl) proceeded smoothly to afford the corresponding aromatic iodides in good to excellent yield. Pyridinium iodochloride has been found to be an efficient solid iodinating reagent with no hazardous effect and it can be handled safely.