215874-86-5 Usage
Description
3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine is a complex organic compound characterized by its unique molecular structure. It is a derivative of phthalazine, which is fused with a triazole and isoxazole ring system. 3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine has potential applications in various fields due to its distinct chemical properties and interactions with biological targets.
Uses
Used in Pharmaceutical Industry:
3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine is used as a pharmaceutical compound for its potential cognitive-enhancing properties. As an α5-selective inverse agonist, it has been shown to enhance cognitive performance in rodents, and there is potential for similar effects in humans. This makes it a promising candidate for the development of drugs targeting cognitive disorders and improving overall cognitive function.
Used in Neuropharmacology:
In the field of neuropharmacology, 3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine is used as a selective modulator of GABAA receptors. By selectively attenuating the effects of GABA at these receptors, it can potentially be used to develop treatments for neurological disorders related to the GABAergic system, such as epilepsy, anxiety, and sleep disorders.
Used in Chemical Research:
3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine can also be used as a research tool in chemical and medicinal chemistry. Its unique structure and properties make it a valuable compound for studying receptor interactions, drug design, and the development of novel therapeutic agents. Researchers can use this compound to gain insights into the mechanisms of action of various biological targets and design more effective drugs for a range of conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 215874-86-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,5,8,7 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 215874-86:
(8*2)+(7*1)+(6*5)+(5*8)+(4*7)+(3*4)+(2*8)+(1*6)=155
155 % 10 = 5
So 215874-86-5 is a valid CAS Registry Number.
215874-86-5Relevant articles and documents
Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers
Sternfeld, Francine,Carling, Robert W.,Jelley, Richard A.,Ladduwahetty, Tamara,Merchant, Kevin J.,Moore, Kevin W.,Reeve, Austin J.,Street, Leslie J.,O'Connor, Desmond,Sohal, Bindi,Atack, John R.,Cook, Susan,Seabrook, Guy,Wafford, Keith,Tattersall, F. David,Collinson, Neil,Dawson, Gerard R.,Castro, José L.,MacLeod, Angus M.
, p. 2176 - 2179 (2007/10/03)
Nonselective inverse agonists at the γ-aminobutyric acidA (GABA-A) benzodiazepine binding site have cognition-enhancing effects in animals but are anxiogenic and can precipitate convulsions. Herein, we describe novel GABA-A α5 subtype inverse agonists leading to the identification of 16 as an orally active, functionally selective compound that enhances cognition in animals without anxiogenic or convulsant effects. Compounds of this type may be useful in the symptomatic treatment of memory impairment associated with Alzheimer's disease and related dementias.
