21661-09-6Relevant articles and documents
Polar Metabolites of the Tropical Green Seaweed Caulerpa taxifolia Which Is Spreading in the Mediterranean Sea: Glycoglycerolipids and Stable Enols (α-Keto Esters)
Mancini, Ines,Guella, Graziano,Defant, Andrea,Luz Candenas,Armesto, Cristina P.,Depentori, Daniela,Pietra, Francesco
, p. 1681 - 1691 (1998)
Examination of the polar components of the green seaweed Caulerpa taxifolia (VAHL) C. AGARDH, which is heavily spreading in the northeastern Mediterranean, led to two families of compounds. The new (2R)-3-O-β-D-galactopyranosyl-1-O-[(7Z,10Z,13Z)-hexadeca-7,10,13-trienoyl]- 2-O-[(9Z,12Z,15Z)-octadeca-1,12,15-trienoyl]-sn-glycerol (2) was isolated in low abundance, like the analogues 1 and 3 already known from freshwater cyanobacteria. The acyl positions in 1-3 were determined by enzymatic methods and the absolute configuration from the O-galactosylglycerol obtained upon alcaline methanolysis. More abundant were the (4-hydroxyphenyl)- and (3,4-dihydroxyphenyl)pyruvic acid methyl esters, occurring in the enol (Z) forms 13a and 14a accompanied by very minor (E) forms 13b and 14b. The latter became predominant on UV irradiation of 13a or 14a, allowing the determination of the C=C configuration of these isolatable, stable enols from 1H,13C NMR couplings (larger H-C(3)/C(1) coupling constant in the (E) than in the (Z) isomer). Contrary to literature implications, the O-galactosylglycerolipids 1-3 lack any cholinergic or histaminergic activity; similarly, enols (= α-keto esters) 13 and 14 or terpenoids of this seaweed were also devoid of such biological activities (see Table).
Linolenic acid-modified PEG-PCL micelles for curcumin delivery
Song, Zhimei,Zhu, Wenxia,Liu, Na,Yang, Fengying,Feng, Runliang
, p. 312 - 321 (2014/06/24)
In this study, a novel linolenic acid-modified poly(ethylene glycol)-b-poly(E-caprolactone) copolymer was prepared through radical addition, ring-opening polymerization, and N-acylation reactions. Its structure was characterized by 1H NMR and GPC. Micelles were developed by thin-film hydration and used as a delivery system for curcumin with high drug loading capacity of 12.80% and entrapment efficiency of 98.53%. The water solubility of curcumin was increased to 2.05 mg/mL, which was approximately 1.87 × 105 times higher than that of free curcumin. The micelles were spherical shape with an average diameter of 20.8 ± 0.8 nm. X-ray diffraction and FT-IR studies suggested that curcumin existed in the polymeric matrices under π-π conjugation and hydrogen bond interaction with the copolymer. In vitro drug release studies indicated that the curcumin release from linolenic acid-modified copolymer micelles met controlled release, and its release rate was less than that from the linolenic acid-unmodified copolymer micelles. Cytotoxicities against Hela and A-549cells demonstrated that the additional π-π conjugation could affect curcumin's anticancer activity through reducing its release from micelles. Hemolysis test and intravenous irritation test results revealed that the linolenic acid-modified copolymer was safe for intravenous injection. The plasma AUC0-∞ and MRT0-∞ of curcumin-loaded linolenic acid-conjugated poly(ethylene glycol)-b-poly(E-caprolactone) copolymer micelles were 2.75- and 3.49-fold higher than that of control solution, respectively. The CLz was also decreased by 2.75-fold. So, this linolenic acid-modified copolymer might be a carrier candidate for curcumin delivery.
HPPE YARNS
-
, (2012/11/08)
The invention relates to a treated HPPE yarn characterized in that the treated HPPE yarn comprises: a porous polyolefin layer that adheres to a surface of a HPPE yarn and covers at least partly the surface of the HPPE yarn; a composition comprising an active agent and which composition is at least partially absorbed within the porous polyolefin layer. The invention further relates to an article comprising the treated HPPE yarn, a device comprising the treated HPPE yarn or the article. The invention also relates to a process for preparing the treated HPPE yarn or treated HPPE yarn structure or treated HPPE yarn configuration and use of the treated HPPE yarn or an article or a device comprising the treated HPPE yarn for automotive applications, marine applications, aerospace applications, medical applications, defense applications, sports/recreational applications, architectural applications, clothing applications, bottling applications, machinery applications.
