217795-77-2Relevant articles and documents
Hydromethylation of Unactivated Olefins
Dao, Hai T.,Li, Chao,Michaudel, Quentin,Maxwell, Brad D.,Baran, Phil S.
supporting information, p. 8046 - 8049 (2015/07/15)
A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or to directly "edit" complex natural products and other advanced materials. The method is also amenable to the simple installation of radioactive and stable labeled methyl groups.
Biohydroxylations of Cbz-protected alkyl substituted piperidines by Beauveria bassiana ATCC 7159
Aitken, Suzanne J.,Grogan, Gideon,Chow, Cathy S.-Y.,Turner, Nicholas J.,Flitsch, Sabine L.
, p. 3365 - 3370 (2007/10/03)
N-Benzyloxycarbonyl (Cbz) protected piperidines are hydroxylated with greater regioselectivity than the corresponding N-benzoyl analogues when incubated with the fungus Beauveria bassiana ATCC 7159. Cbz-protected piperidines 1-3, 5-7, have been biotransfo
