21788-28-3

Basic information

• Product Name: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-
• Synonyms: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-;1-(4-methoxyphenyl)-1,2,3,4-tetrazole;1-(4-Methoxy-phenyl)-1H-tetrazole;1-(4-methoxyphenyl)-1H-tetrazole;1-(4-methoxyphenyl)tetrazole
• CAS NO: 21788-28-3
• Molecular Formula: C₈H₈N₄O
• Molecular Weight: 176.18
• Mol File: 21788-28-3.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 327.9°Cat760mmHg
• Flash Point: 152.1°C
• Appearance: /
• Density: 1.3g/cm³
• CAS DataBase Reference: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-(21788-28-3)
• EPA Substance Registry System: 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)-(21788-28-3)

Safety Data

• Hazardous Substances Data: 21788-28-3(Hazardous Substances Data)

Usage

Description

1H-TETRAZOLE, 1-(4-METHOXYPHENYL)is an organic compound with the molecular formula C8H9N4O. It is characterized by its tetrazole ring fused with a phenyl group, which has a methoxy substituent at the para position. 1H-TETRAZOLE, 1-(4-METHOXYPHENYL)is known for its diverse applications in various fields due to its unique chemical properties and reactivity.

Uses

Used in Synthesis:
1H-TETRAZOLE, 1-(4-METHOXYPHENYL)is used as a synthetic intermediate for the preparation of various complex organic molecules. Its reactivity and structural features make it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in In-Silico Molecular Modeling:
1H-TETRAZOLE, 1-(4-METHOXYPHENYL)is utilized in in-silico molecular modeling to study the structure-activity relationships of various biologically active molecules. Its unique chemical properties allow researchers to predict the behavior of related compounds and design new molecules with improved biological activities.
Used in Pharmaceutical Industry:
1H-TETRAZOLE, 1-(4-METHOXYPHENYL)is used as a key component in the development of anti-diabetic, antibacterial, and antifungal agents. Its incorporation into the molecular structure of these drugs enhances their therapeutic potential and helps in the treatment of various diseases.
Used in Anti-Diabetic Applications:
1H-TETRAZOLE, 1-(4-METHOXYPHENYL)is employed as an anti-diabetic agent, particularly in the development of aryl-N-tosyl-tetrazole-carboxamides. These compounds exhibit potent anti-diabetic activities, making them promising candidates for the treatment of diabetes mellitus.
Used in Antibacterial Applications:
1H-TETRAZOLE, 1-(4-METHOXYPHENYL)is used as an antibacterial agent, contributing to the development of aryl-N-tosyl-tetrazole-carboxamides with potent antibacterial properties. These compounds can be effective against a wide range of bacterial pathogens, offering new treatment options for bacterial infections.
Used in Antifungal Applications:
1H-TETRAZOLE, 1-(4-METHOXYPHENYL)is utilized as an antifungal agent, playing a crucial role in the development of aryl-N-tosyl-tetrazole-carboxamides with significant antifungal activities. These compounds can be effective against various fungal pathogens, providing new therapeutic options for the treatment of fungal infections.

Upstream product

• 100-17-4 para-methoxynitrobenzene 
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• 1895-39-2 sodium chlorodifluoroacetate 
• 104-94-9 4-methoxy-aniline 
• 123-11-5 4-methoxy-benzaldehyde 
• 26060-35-5 N-(4-methoxyphenyl)thioformamide 
• 10349-38-9 p-methoxyphenylisonitrile 
• 5470-34-8 4-methoxyformanilide 

Downstream Products

• 57761-73-6 1-(4'-methoxyphenyl)-5-phenyl-1H-tetrazole 
• 7472-54-0 N-(p-methoxyphenyl)benzamide 
• 1571902-00-5 5-(2,2-dioxido-1,2-benzoxathiin-6-yl)-1-(4-methoxyphenyl)-1H-tetrazole 
• 1352545-35-7 5-(3,4,5-trimethoxyphenyl)-1-(4-methoxyphenyl)-1H-tetrazole 
• 168267-02-5 2-methoxy-5-tetrazol-1-yl-benzaldehyde 

Relevant articles and documents

Removal of the Cd(II), Ni(II), and Pb(II) ions via their complexation with the uric acid-based adsorbent and use of the corresponding Cd-complex for the synthesis of tetrazoles

The magnetic supported uric acid-based compound (Fe3O4@SiO2@CPTMS@UA) was prepared, characterized and used as a capable adsorbent for removal of the Cd(II), Ni(II) and Pb(II) ions from aqueous solution. The Freundlich and Langmuir adsorption isotherms have been used to evaluate the adsorption behaviors. The high correlation coefficient of the Langmuir model (R+2 > 0.99) reveals that the Langmuir model offers the better coordination with the experimental results and so the model of adsorption of Cd2+, Ni2+, and Pb2+ on the adsorbent is more compatible with the Langmuir model, and the maximum adsorption capacity for the Cd, Ni, and Pb ions are about 285.7, 45.06 and 145.09 mg/g. Then, the corresponding Cd-complex (Fe3O4@SiO2@CPTMS@ UA@Cd) was also prepared, characterized and applied as an efficient heterogeneous nano-catalyst for the synthesis of diverse tetrazoles.

Polymer-Supported Fe-Phthalocyanine Derived Heterogeneous Photo-Catalyst for the Synthesis of Tetrazoles Under Visible Light Irradiation

Abstract: Herein, a polymer supported Fe-Phthalocyanine entangled with carboxyl functionalized benzimidazolium moiety (PSFePcCFBM) explored as heterogenous photocatalyst, for regioselective synthesis of 1H-tetrazoles from sodium azide and other affordable

The anchoring of a Cu(ii)-salophen complex on magnetic mesoporous cellulose nanofibers: green synthesis and an investigation of its catalytic role in tetrazole reactions through a facile one-pot route

Today, most synthetic methods are aimed at carrying out reactions under more efficient conditions and the realization of the twelve principles of green chemistry. Due to the importance and widespread applications of tetrazoles in various industries, especially in the field of pharmaceutical chemistry, and the expansion of the use of nanocatalysts in the preparation of valuable chemical reaction products, we decided to use an (Fe3O4@NFC@NSalophCu)CO2H nanocatalyst in this project. In this study, the synthesis of the nanocatalyst (Fe3O4@NFC@NSalophCu)CO2H was explained in a step-by-step manner. Confirmation of the structure was obtained based on FT-IR, EDX, FE-SEM, TEM, XRD, VSM, DLS, TGA, H-NMR, and CHNO analyses. The catalyst was applied to the synthesis of 5-substituted-1H-tetrazole and 1-substituted-1H-tetrazole derivatives through multi-component reactions (MCRs), and the performance was assessed. With advances in science and technology and increasing environmental pollution, the use of reagents and methods that are less dangerous for the environment has received much attention. Therefore, following green chemistry principles, with the help of the (Fe3O4@NFC@NSalophCu)CO2H salen complex as a nanocatalyst that is recyclable, cheap, safe, and available, the use of water as a green solvent, and reduced reaction times, the synthesis of tetrazoles can be achieved.