2183-66-6

Basic information

• Product Name: 2-(METHYLTHIO)PYRIMIDIN-4-AMINE
• Synonyms: 4-Pyrimidinamine, 2-(methylthio)-;2-Methylthio-4-aMinopyriMidine;2-(Methylthio)pyrimidin-4-amine, 4-Amino-2-(methylthio)-1,3-diazine;2-(Methylthio)pyriMidin-4-aMine;2-(METHYLTHIO)PYRIMIDIN-4-AMINE;4-Pyrimidinamine, 2-(methylthio)- (9CI);4-AMINO-2-METHYLSULFANYLPYRIMIDINE;4-Amino-2-methylthiopyrimidine
• CAS NO: 2183-66-6
• Molecular Formula: C₅H₇N₃S
• Molecular Weight: 141.19
• Product Categories: PYRIMIDINE;Amines;Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 2183-66-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 312.9°Cat760mmHg
• Flash Point: 143°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 0.000514mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.22±0.10(Predicted)
• Sensitive: Stench
• CAS DataBase Reference: 2-(METHYLTHIO)PYRIMIDIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLTHIO)PYRIMIDIN-4-AMINE(2183-66-6)
• EPA Substance Registry System: 2-(METHYLTHIO)PYRIMIDIN-4-AMINE(2183-66-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-36/37-39
• WGK Germany: 3
• Hazardous Substances Data: 2183-66-6(Hazardous Substances Data)

Usage

Description

2-(METHYLTHIO)PYRIMIDIN-4-AMINE, also known as 2-Methylsulfanylpyrimidin-4-amine, is an organic compound with the chemical formula C5H6N2S. It is a white solid and belongs to the class of heterocyclic compounds, specifically pyrimidines, which are fused heterocyclic compounds consisting of a six-membered ring with four carbon atoms and two nitrogen atoms. The presence of a methylthio group (-SCH3) attached to the second carbon atom of the pyrimidine ring gives this compound its unique chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
2-(METHYLTHIO)PYRIMIDIN-4-AMINE is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a versatile building block in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Synthesis:
In the field of organic chemistry, 2-(METHYLTHIO)PYRIMIDIN-4-AMINE is used as a starting material for the preparation of various derivatives, such as pentafluorobenzyl derivatives. These derivatives may have potential applications in different industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
Due to its unique chemical properties and potential for modification, 2-(METHYLTHIO)PYRIMIDIN-4-AMINE is also used in research and development for the exploration of new chemical reactions, synthesis methods, and the discovery of novel compounds with specific biological activities or material properties.

InChI:InChI=1/C5H7N3S/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3,(H2,6,7,8)

Upstream product

• 76064-23-8 3-hydroxyacrylonitrile sodium salt 
• 867-44-7 S-Methylisothiourea sulfate 
• 4338-95-8 S-methylthiouronium iodide 
• 61310-53-0 3-ethoxyacrylonitrile 
• 74-88-4 methyl iodide 
• 333-49-3 2-thiocytosine 
• 49844-90-8 4-Chloro-2-methylthiopyrimidine 

Downstream Products

• 71-30-7 Cytosine 
• 1429658-37-6 C₁₁H₉ClN₄O₂S 
• 1425495-59-5 C₁₁H₁₁ClN₄S 
• 1147530-57-1 C₁₀H₁₀ClN₅OS 

Relevant articles and documents

Process for synthesis of cytosine

The invention discloses a process for synthesizing cytosine. A 3-hydroxyacrylonitrile compound and an O-methylisourea compound or an S-methylisothiourea compound or an S-ethylisothiourea compound or an S-benzylisothiourea compound are used as raw materials. The process comprises the steps of adding a catalyst and an organic solvent into a reaction kettle, stirring, and then adding the raw materials; heating the mixture to be 50-90 DEG C, and reacting for 8-12 hours; evaporating the solvent to obtain an intermediate; adding concentrated hydrochloric acid into the intermediate, heating to be 70-100 DEG C, and preserving the heat for 1-2 hours; adding water, performing hot filtration, and cooling the obtained filtrate to room temperature; dripping a sodium hydroxide solution into the filtrate to adjust the pH value to be 7-7.5, and cooling to 10-15 DEG C; filtering after cooling, washing, and drying to obtain the cytosine. The process has the advantages that the process steps are simple, the production period is short, and the cost is low; the conversion rate of the raw materials is high, and the synthesized product is good in quality and high in yield, so that the process is suitable for industrialized production.

INHIBITORS OF POLO-LIKE KINASES

Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Novel cephalosporin compounds and processes for the preparation thereof

The present invention relates to novel cephalosporin compounds, pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates and isomers thereof which possess potent and broad antibacterial activities. The compounds of the present invention have a (1,5,6-substituted-4-aminopyrimidinium-2-yl)thiomethyl group in 3-position of the cephem nucleus and is specifically represented by the following formula(I): ψψψ