218434-90-3

Basic information

• Product Name: Benzene, 1-[(3-butynyloxy)methyl]-4-methoxy-
• CAS NO: 218434-90-3
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol File: 218434-90-3.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(3-butynyloxy)methyl]-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(3-butynyloxy)methyl]-4-methoxy-(218434-90-3)
• EPA Substance Registry System: Benzene, 1-[(3-butynyloxy)methyl]-4-methoxy-(218434-90-3)

Safety Data

• Hazardous Substances Data: 218434-90-3(Hazardous Substances Data)

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 927-74-2 3-Butyn-1-ol 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 2746-25-0 p-Methoxybenzyl bromide 
• 70887-29-5 4-methoxybenzyl iodide 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 851532-53-1 (2R)-5-hydroxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne 
• 254891-78-6 (2S)-5-hydroxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne 
• 913975-66-3 (+/-)-(E)-3-hydroxy-7-(4-methoxybenzyloxy)hept-4-enyl pivalate 
• 495406-24-1 5-hydroxymethyl-6-[4-(4-methoxybenzyloxy)-(E)-1-butenyl]-2,2-dimethyl-(3aR,5R,6R,6aR)-perhydrofuro[2,3-d][1,3]dioxol-6-ol 
• 495406-27-4 5-tert-butyldimethylsilyloxymethyl-6-[4-(4-methoxybenzyloxy)-(E)-1-butenyl]-2,2-dimethyl-(3aR,5R,6R,6aR)-perhydrofuro[2,3-d][1,3]dioxol-6-ol 
• 495406-28-5 1-[6-hydroxy-5-tert-butyldimethylsilyloxymethyl-2,2-dimethyl-(3aR,5R,6R,6aR)-perhydrofuro[2,3-d][1,3]dioxol-6-yl]-4-(4-methoxybenzyloxy)-(1R,2S)-butane-1,2-diol 
• 495406-31-0 1-[6-hydroxy-5-tert-butyldimethylsilyloxymethyl-2,2-dimethyl-(3aR,5R,6R,6aR)-perhydrofuro[2,3-d][1,3]dioxol-6-yl]-4-(4-methoxybenzyloxy)-(1S,2R)-butane-1,2-diol 
• 495406-29-6 1-[6-hydroxy-5-tert-butyldimethylsilyloxymethyl-2,2-dimethyl-(3aR,5R,6S,6aR)-perhydrofuro[2,3-d][1,3]dioxol-6-yl]-4-(4-methoxybenzyloxy)-2-methylcarbonyloxy-(1R,2S)-butyl acetate 
• 1000153-21-8 (4-(4-methoxybenzyloxy)but-1-ynyl)trimethylsilane 
• 1160163-70-1 C₂₂H₂₆O₄ 
• 1265903-85-2 1-cyclohexyl-5-(4-methoxybenzyloxy)pent-2-yn-1-ol 
• 1265903-96-5 2-[(1-cyclohexyl-5-(4-methoxybenzyloxy)pent-2-ynyl)thio]benzo[d]thiazole 
• 1265904-04-8 2-[(1-cyclohexyl-5-(4-methoxybenzyloxy)pent-2-ynyl)sulfonyl]benzo[d]thiazole 
• 1265904-08-2 1-cyclohexyl-5-[para-methoxybenzyloxy]penta-1,2-diene 

Relevant articles and documents

Synthesis of Optically Active Maresin 2 and Maresin 2 n-3 DPA

Maresins are among the most potent antiinflammatory lipid metabolites. We report stereoselective syntheses of maresin 2 and maresin 2 n-3 DPA. The anti -diol was constructed through epoxide ring opening of an optically active β,γ-epoxy aldehyde, synthesized in situ by Swern oxidation of the corresponding alcohol. Finally, the target compounds were synthesized through a Sonogashira coupling of a C9-C22 iodide and methyl (Z)-oct-4-en-7-ynoate or methyl oct-7-ynoate, respectively.

Regio- and stereoselective SN2′ reaction of an allylic picolinate in the synthesis of LY426965

Allylic substitution of secondary γ,γ-disubstituted allylic picolinates with ArMgBr-based copper reagents was applied to the synthesis of LY426965. Reduction of (R)-6-(PMB-oxy)-3-hexyn-2-ol of 93% ee (PMB = p-MeOC6H4CH2) using Red-Al gave (R,Z)-4-iodo-5-(PMB-oxy)hex-3-en-2-ol, which was later converted to the Me-substituted allylic picolinate by Pd-catalyzed coupling with MeZnI followed by esterification with picolinic acid. Allylic substitution with PhMgBr/Cu(acac)2 proceeded with high anti SN2′ selectivity (99%). Ozonolysis, addition of c-Hex-MgBr to the resulting aldehyde, and reductive amination with the piperazine derivative afforded LY426965.

Stereodivergent Intramolecular C(sp3)-H Functionalization of Azavinyl Carbenes: Synthesis of Saturated Heterocycles and Fused N -Heterotricycles

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