21846-08-2

Basic information

• Product Name: 4-(9H-fluoren-9-yl)phenyl methyl ether
• Synonyms: 9-(4-METHOXYPHENYL)-9H-FLUORENE
• CAS NO: 21846-08-2
• Molecular Formula: C₂₀H₁₆O
• Molecular Weight: 272.3404
• Mol File: 21846-08-2.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 414.8°C at 760 mmHg
• Flash Point: 168.5°C
• Density: 1.151g/cm³
• Vapor Pressure: 1.04E-06mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: 4-(9H-fluoren-9-yl)phenyl methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(9H-fluoren-9-yl)phenyl methyl ether(21846-08-2)
• EPA Substance Registry System: 4-(9H-fluoren-9-yl)phenyl methyl ether(21846-08-2)

Safety Data

• Hazardous Substances Data: 21846-08-2(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 57028-27-0 9-(4-methoxyphenyl)-9H-fluoren-9-ol 
• 141-53-7 sodium formate 
• 1689-64-1 9-Fluorenol 
• 100-66-3 methoxybenzene 
• 12257-35-1 9-fluorenyl carbocation 
• 1065544-00-4 (biphenyl-2-yl)(4-methoxyphenyl)methanol 
• 1065544-24-2 acetic acid (biphenyl-2-yl)(4-methoxyphenyl)methyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 14202-31-4 4-methoxybenzaldehyde-1,1-diacetate 
• 486-25-9 9-fluorenone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1016-05-3 dibenzothiophene sulfone 
• 104-47-2 p-methoxybenzylnitrile 

Relevant articles and documents

Transition-Metal-Free Synthesis of Polyfunctional Triarylmethanes and 1,1-Diarylalkanes by Sequential Cross-Coupling of Benzal Diacetates with Organozinc Reagents

A variety of functionalized triarylmethane and 1,1-diarylalkane derivatives were prepared via a transition-metal-free, one-pot and two-step procedure, involving the reaction of various benzal diacetates with organozinc reagents. A sequential cross-coupling is enabled by changing the solvent from THF to toluene, and a two-step SN1-type mechanism was proposed and evidenced by experimental studies. The synthetic utility of the method is further demonstrated by the synthesis of several biologically relevant molecules, such as an anti-tuberculosis agent, an anti-breast cancer agent, a precursor of a sphingosine-1-phosphate (S1P) receptor modulator, and a FLAP inhibitor.

KHMDS mediated synthesis of 9-arylfluorenes from dibenzothiophene dioxides and arylacetonitriles by tandem SNAr-decyanation-based arylation

A straightforward KHMDS mediated synthetic route to 9-arylfluorenes from readily available starting materials has been developed. This reaction involves SNAr reactions of dioxide with arylacetonitriles, followed by decyanation reaction. The pro

LDA-Mediated Synthesis of Triarylmethanes by Arylation of Diarylmethanes with Fluoroarenes at Room Temperature

A practical and convenient approach for the secondary C(sp3)-H arylation of diarylmethanes with various fluoroarenes is described. The reaction proceeds smoothly in the presence of LDA (lithium diisopropylamide) at room temperature and affords triarylmethanes in moderate to high yields.