219625-03-3

Basic information

• Product Name: (2R)-N-(4-phenoxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexylmethyl-thiopropanamide
• Synonyms: (2R)-N-(4-phenoxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexylmethyl-thiopropanamide
• CAS NO: 219625-03-3
• Molecular Weight: 498.687
• Mol File: 219625-03-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R)-N-(4-phenoxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexylmethyl-thiopropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-N-(4-phenoxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexylmethyl-thiopropanamide(219625-03-3)
• EPA Substance Registry System: (2R)-N-(4-phenoxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexylmethyl-thiopropanamide(219625-03-3)

Safety Data

• Hazardous Substances Data: 219625-03-3(Hazardous Substances Data)

Upstream product

• 169944-04-1 (4-phenoxyphenyl)methanamine monohydrochloride 
• 25952-53-8 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 
• 219626-94-5 (2R)-2-(t-butoxycarbonylamino)-3-cyclohexylmethylthiopropanoic acid 
• 2550-36-9 Cyclohexylmethyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 107622-80-0 4-phenoxybenzylamine 
• 473421-00-0 (R)-2-Amino-3-cyclohexylmethylsulfanyl-propionic acid 

Downstream Products

• 255735-68-3 (2R)-N-(4-phenoxybenzyl)-2-amino-3-cyclohexylmethylthiopropanamide · hydrochloride 
• 219626-50-3 (2R)-N-(4-phenoxybenzyl)-3-cyclohexylmethylthio-2-((4R)-thiazolidin-4-ylcarbonylamino)propanamide 
• 219625-92-0 (R)-4-[(R)-2-Cyclohexylmethylsulfanyl-1-(4-phenoxy-benzylcarbamoyl)-ethylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester 
• 473421-33-9 2-amino-3-cyclohexylmethylsulfanyl-N-(4-phenoxy-benzyl)-propionamide 

Relevant articles and documents

Amino acid derivatives

A compound of the formula (1): [wherein R1 is (substituted) alkyl, alkoxy, phenyl, hetero ring etc.; A is bond, CO, SO2; R2 is H, (substituted) alkyl etc.; D is alkylene etc.; E is COO, OCO, O, S, SO, SO2 etc.;

Structure-activity study of L-cysteine-based N-type calcium channel blockers: optimization of N- and C-terminal substituents.

Synthesis and structure-activity relationship (SAR) studies of L-cysteine-based N-type calcium channel blockers are described. In the course of exploring SAR of the N- and C-terminal substituents, the L-cysteine derivative was found to be a potent N-type calcium channel blocker with an IC(50) value of 0.14 microM on IMR-32 assay. Compound showed 12-fold selectivity for N-type over L-type calcium channels on AtT-20 assay.