21969-70-0

Basic information

• Product Name: 2-ANILINOACETAMIDE
• Synonyms: Phenylglycinamide
• CAS NO: 21969-70-0
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Mol File: 21969-70-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 385.762°C at 760 mmHg
• Flash Point: 187.102°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 2-ANILINOACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ANILINOACETAMIDE(21969-70-0)
• EPA Substance Registry System: 2-ANILINOACETAMIDE(21969-70-0)

Safety Data

• Hazardous Substances Data: 21969-70-0(Hazardous Substances Data)

Usage

Description

2-Anilinoacetamide is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and has significant applications in the pharmaceutical industry due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
2-Anilinoacetamide is used as an initial substrate for the enzymic synthesis of Cephalexin (C256800) with liquid penicillin G acylase. This application is important because it plays a vital role in the production of Cephalexin, a widely used antibiotic that belongs to the cephalosporin group of antibiotics. Cephalexin is effective against a broad range of bacterial infections, making 2-Anilinoacetamide a valuable compound in the development and synthesis of essential medications.

InChI:InChI=1/C8H10N2O/c9-8(11)6-10-7-4-2-1-3-5-7/h1-5,10H,6H2,(H2,9,11)

Upstream product

• 3009-97-0 N-phenylglycinonitrile 
• 1668-10-6 glycinamide hydrochloride 
• 66003-76-7 Diphenyliodonium triflate 
• 2216-92-4 N-phenylglycine ethyl ester 
• 62-53-3 aniline 
• 103-01-5 N-Phenylglycine 
• 103-70-8 Formanilid 
• 586-96-9 Nitrosobenzene 
• 861071-17-2 N,N'-diphenyl-N,N'-oxalyl-bis-glycine diethyl ester 
• 7664-41-7 ammonia 
• 490-56-2 3-phenyl-oxazolidine-2,5-dione 
• 178869-03-9 2,6-diphenyl-1-oxa-2,5-diaza-4-oxo-cyclohexane 
• 861321-16-6 N-anilinomethyl formanilide 
• 151-50-8 potassium cyanide 

Downstream Products

• 10242-60-1 N-nitroso-N-phenyl-glycine amide 
• 213995-52-9 2-(4-bromophenylamino)acetamide 
• 42239-75-8 4-phenylpiperazine-2,6-dione 
• 103-01-5 N-Phenylglycine 
• 1346234-64-7 4-chloro-2-(2-chlorophenyl)-1-phenyl-1H-imidazole-5-carbaldehyde 
• 1346234-57-8 N-(2-amino-2-oxoethyl)-2-chloro-N-phenylbenzamide 
• 1346234-65-8 4-chloro-2-(4-nitrophenyl)-1-phenyl-1H-imidazole-5-carbaldehyde 
• 1030737-19-9 N-(2-amino-2-oxoethyl)-N-phenyl-4-nitrobenzamide 
• 1181491-60-0 1-phenyl-4-chloro-1H-imidazole-5-carbaldehyde 
• 611-71-2 MANDELIC ACID 
• 4801-39-2 2-amino-N-phenylacetamide hydrochloride 
• 108774-91-0 2-methyl-5-(3-methyl-3H-benzothiazol-2-ylidene)-1-phenyl-1,5-dihydro-imidazol-4-one 
• 15414-78-5 1-phenylhydantoin 
• 101777-79-1 N-(N-phenyl-glycyl)-glycine diethylamide 

Relevant articles and documents

Selective C-N coupling reaction of diaryliodonium salts and dinucleophiles

N-Aryl-α-amino amides including their chiral isomers have demonstrated important applications as pharmaceutical drugs; however, to date, a one-step synthetic route for them still remains to be developed. Herein, an efficient ligand-free copper-catalyzed selective C-N coupling reaction of diaryliodonium salts and dinucleophiles under mild conditions was realized. Diaryliodonium salts prefer to react with dinucleophiles at the site of stronger alkalic amino groups. Thus, a general aliphatic amino-selective N-arylation of α-amino amides was disclosed. Additionally, copper-catalyzed N-arylation of diaryliodonium salts afforded the same products as obtained via palladium-catalyzed reactions of aryl halides.

4-OXOIMIDAZOLIDINE-2-SPIROPIPERIDINE DERIVATIVE

The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I] ???[in which A1, A2, A3, A4 and A5 stand for optionally halogen-substituted methine, or nitrogen atom; R1 and R2 stand for lower alkyl or the like; R3 stands for hydrogen or lower alkyl; R4 and R5 stand for hydrogen, or lower alkyl which is optionally substituted with hydroxy, or the like] or salts thereof. These compounds act as nociceptin receptor agonist, and are useful as analgesic, reliever from tolerance to narcotic analgesic, reliever from dependence on narcotic analgesic, analgesic enhancer, antiobestic, drug for ameliorating brain function, remedy for schizophrenia, drug for treating regressive neurodegenerative diseases, antianxiety agent or antidepressant and remedy for diabetes insipidus and polyuria; and the like.

PROCESS FOR THE ENZYMATIC PREPARATION OF A BETA-LACTAM DERIVATIVE AND SEPARATION OF D-PHENYLGLYCINE AMIDE

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