15414-78-5

Basic information

• Product Name: 2,4-Imidazolidinedione, 1-phenyl-
• CAS NO: 15414-78-5
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Mol File: 15414-78-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2,4-Imidazolidinedione, 1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Imidazolidinedione, 1-phenyl-(15414-78-5)
• EPA Substance Registry System: 2,4-Imidazolidinedione, 1-phenyl-(15414-78-5)

Safety Data

• Hazardous Substances Data: 15414-78-5(Hazardous Substances Data)

Usage

Appearance

White crystalline powder

Primary Use

Antiepileptic drug

Function

Reduces the spread of seizure activity in the brain

Types of Seizures Treated

Tonic-clonic, complex partial, and pentylenetetrazol-induced seizures

Additional Properties

Antiarrhythmic and neuropathic pain-relieving

Safety Considerations

Potentially serious side effects and interactions with other medications; should only be used under the guidance of a healthcare professional.

Upstream product

• 590-28-3 potassium cyanate 
• 103-01-5 N-Phenylglycine 
• 57-13-6 urea 
• 4791-23-5 N-chloroacetyl-N'-phenylurea 
• 7732-18-5 water 
• 151-50-8 potassium cyanide 
• 62-53-3 aniline 
• 2216-92-4 N-phenylglycine ethyl ester 
• 461-72-3 2,4-imidazolidinedione 
• 591-50-4 iodobenzene 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 1034186-50-9 methyl N-cyano-N-phenylaminoacetate 
• 21969-70-0 2-anilinoacetamide 
• 64-10-8 phenyl carbamate 

Downstream Products

• 55889-14-0 3-methyl-1-phenylhydantoin 
• 10395-14-9 3-acetyl-1-phenyl-imidazolidine-2,4-dione 
• 32549-34-1 1-(4-Bromophenyl)imidazolidine-2,4-dione 
• 480-93-3 indoxyl 
• 93744-08-2 1-(2-aminoethyl)-2,4-dioxo-3-phenyl-1H,3H-imidazolidine 
• 112109-47-4 3-(3-bromo-propyl)-1-phenyl-imidazolidine-2,4-dione 
• 33584-02-0 N-hydroxymethyl-N'-phenyl hydantoin 
• 177711-33-0 3(4-chlorobenzoyl)-1phenyl-imidazolidin-2,4-dione 
• 33588-81-7 3-bromomethyl-1-phenyl-imidazolidine-2,4-dione 
• 112108-92-6 3-(3-mercaptopropyl)-1-phenyl-2,4-dioxoimidazolidine 
• 131769-21-6 (S)-(-)-1-<2-<3-(2-cyanophenoxy)-2-hydroxypropyl>aminoethyl>-2,4-dioxo-3-phenyl-1H,3H-imidazolidine 
• 131769-23-8 (R)-(+)-1-<2-<3-(2-cyanophenoxy)-2-hydroxypropyl>aminoethyl>-2,4-dioxo-3-phenyl-1H,3H-imidazolidine 
• 177711-37-4 1-phenyl-3-(3-methoxybenzoyl)-imidazolidin-2,4-dione 
• 177711-38-5 3-(2.6-dimethylbenzoyl)-1-phenyl-imidazolidin-2,4-dione 

Relevant articles and documents

Structural and conformational studies of 5-(1H-pyrrol-2-ylmethylene)-substituted imidazolidine-2,4-diones and thiazolidine-2,4-diones

Some imidazolidine-2,4-dione (hydantoin) and thiazolidine-2,4-dione (TZD) derivatives with a 1H-pyrrol-2-ylmethylene substituent at the 5-position (1-8) have been synthesized via an aldol condensation reaction. A mixture of Z- and E- stereoisomers was obt

Synthesis of Five-Membered Cyclic Guanidines via Cascade [3 + 2] Cycloaddition of α-Haloamides with Organo-cyanamides

The convenient preparation of N2-unprotected five-membered cyclic guanidines was achieved through a cascade [3 + 2] cycloaddition between organo-cyanamides and α-haloamides under mild conditions in good to excellent yields (up to 99%). The corresponding cyclic guanidines could be easily transformed into hydantoins via hydrolysis.

Highly efficient dialkylphosphate-mediated syntheses of hydantoins and a bicyclohydantoin under solvent-free conditions

Diversely substituted hydantoins have been synthesized by new strategy from cyanamide based precursor, that is, methyl N-cyano-N-alkyl/arylaminoacetate. Dialkylphosphates were employed as the mild reagent to hydrolyze and cyclize the substrate in one step to give quantitative yields of the desired products. Syntheses of multivalent hydantoins viz bis-hydantoin, bicyclohydantoin have potentially widened the scope and applicability of the present method. Solvent-free conditions and very easy work-up procedure make the reaction convenient and eco-friendly. Single crystal structures of some of the representative compounds are also reported.