219926-39-3

Basic information

• Product Name: 3-Bromo-2,6-difluorophenyltrimethylsilane
• Synonyms: 3-Bromo-2,6-difluorophenyltrimethylsilane
• CAS NO: 219926-39-3
• Molecular Weight: 265.173
• Mol File: 219926-39-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Bromo-2,6-difluorophenyltrimethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2,6-difluorophenyltrimethylsilane(219926-39-3)
• EPA Substance Registry System: 3-Bromo-2,6-difluorophenyltrimethylsilane(219926-39-3)

Safety Data

• Hazardous Substances Data: 219926-39-3(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 348-57-2 2,4-difluorobromobenzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 148854-10-8 (2,4-difluorophenyl)trimethylsilane 

Downstream Products

• 219926-41-7 1,3-Dibromo-2,4-difluorobenzene 

Relevant articles and documents

Deprotonative Silylation of Aromatic C-H Bonds Mediated by a Combination of Trifluoromethyltrialkylsilane and Fluoride

A method for the deprotonative silylation of aromatic C-H bonds has been developed using trifluoromethyltrimethylsilane (CF3SiMe3, Ruppert-Prakash reagent) and a catalytic amount of fluoride. In this reaction, CF3SiMe3 is considered to act as a base and a silicon electrophile. This process is highly tolerant to various functional groups on heteroarenes and benzenes. Furthermore, this method can be applied to the synthesis of trimethylsilyl group-containing analogs of TAC-101, which is a bioactive synthetic retinoid with selective affinity for retinoic acid receptor α (RAR-α) binding. We also report further transformations of the silylated products into useful derivatives.