348-57-2 Usage
Description
1-Bromo-2,4-difluorobenzene is an organic compound characterized by the presence of a bromine atom at the 1st position and two fluorine atoms at the 2nd and 4th positions on a benzene ring. It is a clear, colorless to brown liquid and undergoes lithiation exclusively at the position with two adjacent halogen substituents, resulting in the formation of 6-bromo-2,3-difluorobenzoic acid.
Uses
1. Used in Pharmaceutical Industry:
1-Bromo-2,4-difluorobenzene is used as a key intermediate for the enantiomeric preparation of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one, which is crucial in the synthesis of chiral azole antifungal agents. This application is significant in the development of new drugs to combat fungal infections.
2. Used in Chemical Synthesis:
1-Bromo-2,4-difluorobenzene serves as a valuable building block in the synthesis of various organic compounds due to its unique structural features, including the presence of a bromine atom and two fluorine atoms on the benzene ring. This makes it a versatile starting material for the creation of a wide range of chemical products.
3. Used in Research and Development:
In the field of research and development, 1-Bromo-2,4-difluorobenzene is utilized as a reagent for studying the properties and reactions of halogenated aromatic compounds. Its lithiation reaction at the position with two adjacent halogen substituents provides insights into the reactivity and selectivity of such compounds, which can be useful for designing new synthetic routes and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 348-57-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 348-57:
(5*3)+(4*4)+(3*8)+(2*5)+(1*7)=72
72 % 10 = 2
So 348-57-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H3Cl2F/c7-4-1-2-5(8)6(9)3-4/h1-3H
348-57-2Relevant articles and documents
Bromination of aromatic compounds using an Fe2O 3/zeolite catalyst
Nishina, Yuta,Takami, Keishi
supporting information, p. 2380 - 2383 (2013/02/21)
The catalytic bromination of non-activated aromatic compounds has been achieved using an Fe2O3/zeolite catalyst system. FeBr 3 was identified as the catalytic species, formed in situ from HBr and Fe2O3. The catalyst was easy-to-handle and cost effective and could also be recycled. The reaction system was also amenable to the one-pot sequential bromination/C-C bond formation of benzene.
Chemoselective bromodeboronation of organotrifluoroborates using tetrabutylammonium tribromide: Application in (Z)-dibromoalkene syntheses
Yao, Min-Liang,Reddy, Marepally Srinivasa,Li, Yong,Walfish, Ingrid,Blevins, David W.,Kabalka, George W.
supporting information; experimental part, p. 700 - 703 (2010/04/02)
(Chemical Equation Presented) Tetrabutylammonlum trlbromlde (TBATB) has been found to be a unique bromodeboronatlon reagent for organotrlf luoroborates. When compared to previously reported bromodeboronatlon methods, the mild and metal-free reaction conditions tolerate a wider range of functional groups. High reglo- and chemoselectlvlty are observed In the presence of both unsaturated carbon-carbon bonds and aldehyde functional groups. An efficient synthetic route to (Z)-dlbromoalkenes from terminal alkynes has been developed using the TBATB-medlated bromodeboronatlon as a key step.
Method for producing tetrakis ( fluoroaryl) borate-magnesium compound
-
, (2008/06/13)
Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.
