220060-17-3

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S)-
• Synonyms: 1,2-Pyrrolidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S)-
• CAS NO: 220060-17-3
• Molecular Weight: 243.303
• Mol File: 220060-17-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S)-(220060-17-3)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S)-(220060-17-3)

Safety Data

• Hazardous Substances Data: 220060-17-3(Hazardous Substances Data)

Usage

Type of compound

Chemical compound

Derivative of

Pyroglutamic acid

Amino acid derivative

Found in various natural sources

Utilization

Pharmaceutical industry

Application

Synthesis of various drugs and bioactive compounds

Structure

Unique structure and properties

Role

Valuable component in the production of new chemical entities and pharmaceuticals

Upstream product

• 42856-71-3 (S)-2-methylpyrrolidine-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109837-32-3 methyl (S)-2-methylpyrrolidine-2-carboxylate 
• 103336-06-7 N-(tert-butoxycarbonyl)-2-methyl-L-proline 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 147-85-3 L-proline 
• 220060-08-2 methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride 

Downstream Products

• 851028-60-9 (S)-tert-butyl 2-formyl-2-methylpyrrolidine-1-carboxylate 
• 1339022-10-4 tert-butyl (2S)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate 
• 103336-06-7 N-(tert-butoxycarbonyl)-2-methyl-L-proline 

Relevant articles and documents

N-Terminal Selective C?H Azidation of Proline-Containing Peptides: a Platform for Late-Stage Diversification

A methodology for the C?H azidation of N-terminal proline-containing peptides was developed employing only commercially available reagents. Peptides bearing a broad range of functionalities and containing up to 6 amino acids were selectively azidated at the carbamate-protected N-terminal residue in presence of the numerous other functional groups present on the molecules. Post-functionalizations of the obtained aminal compounds were achieved: cycloaddition reactions or C?C bond formations via a sequence of imine formation/nucleophilic addition were performed, offering an easy access to diversified peptides.

TRIAZINE KINASE INHIBITORS

The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents.