22038-86-4

Basic information

• Product Name: (R)-(+)-1-(4-Methoxyphenyl)ethylamine
• Synonyms: (R)-p-Methoxyphenylethylamine;Benzenemethanamine, 4-methoxy-.alpha.-methyl-, (.alpha.R)-;(1R)-1-(4-Methoxyphenyl)ethylamine;(R)-(+)-4-Methoxy-alpha-MethylbenzylaMine ChiPros(R), produced by BASF, 99%;R - the Methoxy phenethylaMine;(R)-(+)-4-Methoxy-;(R)-(+)-1-(4-Methoxyphenyl)ethylamine, 99%, ee 99+%;(R)-(+)-4-METHOXY-ALPHA-METHYLBENZYLAMIN
• CAS NO: 22038-86-4
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• EINECS: -0
• Product Categories: API intermediates;Amines (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Amines and Derivatives;CHIRAL CHEMICALS
• Mol File: 22038-86-4.mol
• Article Data: 48

Chemical Properties

• Melting Point: <-20°C
• Boiling Point: 65°C 0,4mm
• Flash Point: 65°C/0.38mm
• Appearance: /
• Density: 1.024 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0383mmHg at 25°C
• Refractive Index: n20/D 1.533
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.29±0.10(Predicted)
• Water Solubility: Soluble in water (10g/L).
• Sensitive: Air Sensitive
• BRN: 2413029
• CAS DataBase Reference: (R)-(+)-1-(4-Methoxyphenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-(4-Methoxyphenyl)ethylamine(22038-86-4)
• EPA Substance Registry System: (R)-(+)-1-(4-Methoxyphenyl)ethylamine(22038-86-4)

Safety Data

• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• F: 10-34
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 22038-86-4(Hazardous Substances Data)

Usage

Description

(R)-(+)-1-(4-Methoxyphenyl)ethylamine, also known as (R)-(+)-4-Methoxy-α-methylbenzylamine, is a colorless liquid with significant applications in the field of organic chemistry. It is a chiral amine derivative that plays a crucial role in various chemical reactions and the synthesis of different compounds.

Uses

Used in Pharmaceutical Industry:
(R)-(+)-1-(4-Methoxyphenyl)ethylamine is used as a reactant for the preparation of enantiopure stereoisomers of hemicryptophanes, which are essential for the recognition of glucopyranosides. This application is vital in the development of drugs targeting specific biological molecules.
Used in Organic Chemistry:
(R)-(+)-1-(4-Methoxyphenyl)ethylamine is used as a reactant for the synthesis of bicyclic Geissman-Waiss lactone through an intramolecular ring-closure reaction of the diastereomeric mixture of sulfonium salts. This reaction is crucial in the preparation of complex organic molecules with potential applications in various fields.
Used in Chemical Synthesis:
(R)-(+)-1-(4-Methoxyphenyl)ethylamine is used as a reactant to prepare N-[(1R)-1-(4-Methoxyphenyl)ethyl]-N′-methylthiourea by reacting with methyl isothiocyanate. (R)-(+)-1-(4-Methoxyphenyl)ethylamine has potential applications in various chemical and pharmaceutical processes.
Used in Diastereo-and Enantioselective Michael Addition Reactions:
(R)-(+)-1-(4-Methoxyphenyl)ethylamine is used as a reactant in diastereo-and enantioselective Michael addition reactions, which are essential for the synthesis of chiral compounds with specific configurations. These reactions are crucial in the development of drugs with improved selectivity and reduced side effects.

InChI:InChI=1/C9H13NO/c1-7(10)8-3-5-9(11-2)6-4-8/h3-7H,10H2,1-2H3/t7-/m1/s1

Upstream product

• 122-84-9 4-methoxybenzyl methyl ketone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 70249-37-5 3-aminocyclohexa-1,5-dienecarboxylic acid 
• 6298-96-0 1-(4-methoxyphenyl)ethanamine 
• 1384127-07-4 N-octanoyl dimethyl glycine trifluoroethyl ester 
• 1034926-69-6 (E)-4-methoxyacetophenone oxime O-2-nitrobenzyl ether 
• 143589-99-5 (1S)-N-benzyloxycarbonyl-1-(4-methoxy-phenyl)ethylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 14429-17-5 anti-N-(α-methyl-4-methoxybenzylidene)benzylamine 
• 141-78-6 ethyl acetate 
• 80965-21-5 (E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime 
• 188198-35-8 [(S)-1-(4-Methoxy-phenyl)-ethyl]-dimethyl-borane 
• 637-69-4 4-Methoxystyrene 
• 185527-01-9 N-[1-(4-Methoxy-phenyl)-ethyl]-oxalamic acid octyl ester 

Downstream Products

• 100-41-4 ethylbenzene 
• 6298-96-0 1(R)-(4-methoxyphenyl)-ethylamine 
• 1125576-35-3 (R)-N-(1-(4-methoxyphenyl)ethyl)-4-methyl-benzenesulfonamide 
• 1198785-54-4 (S)-5-fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(5,5,5-trifluoro-2-methyl-4-oxopentan-2-yl)benzamide 
• 926657-20-7 (3S,4R)-4-(4-Benzyloxy-phenyl)-3-(4-fluoro-phenyl)-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-azetidin-2-one 
• 926657-19-4 (3R,4S)-4-(4-Benzyloxy-phenyl)-3-(4-fluoro-phenyl)-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-azetidin-2-one 
• 947522-58-9 C₁₁H₁₅NO₂ 
• 82776-14-5 (S)-N-[1-(4-methoxyphenyl)ethyl]acetamide 
• 404954-28-5 (R)-N-(1-(4-methoxyphenyl)ethyl)benzamide 

Relevant articles and documents

Reduction of amines with isopropylidene glycerol hydrogen phthalate

The hydrogen phthalate of isopropylidene glycerol has been recently described as an efficient resolving agent of 1-arylethylamines. In order to gain more information on its versatility and to develop a rationale which accounts for its effectiveness, further 1-arylethylamines and other racemic amines were subjected to the same resolution process. A preliminary qualitative analysis of the results reported herein allows to identify some structural features of the aminic substrates conditioning the feasibility of the resolution.

Engineering the large pocket of an (S)-selective transaminase for asymmetric synthesis of (S)-1-amino-1-phenylpropane

Amine transaminases offer an environmentally benign chiral amine asymmetric synthesis route. However, their catalytic efficiency towards bulky chiral amine asymmetric synthesis is limited by the natural geometric structure of the small pocket, representing a great challenge for industrial applications. Here, we rationally engineered the large binding pocket of an (S)-selective ?-transaminase BPTA fromParaburkholderia phymatumto relieve the inherent restriction caused by the small pocket and efficiently transform the prochiral aryl alkyl ketone 1-propiophenone with a small substituent larger than the methyl group. Based on combined molecular docking and dynamic simulation analyses, we identified a non-classical substrate conformation, located in the active site with steric hindrance and undesired interactions, to be responsible for the low catalytic efficiency. By relieving the steric barrier with W82A, we improved the specific activity by 14-times compared to WT. A p-p stacking interaction was then introduced by M78F and I284F to strengthen the binding affinity with a large binding pocket to balance the undesired interactions generated by F44. T440Q further enhanced the substrate affinity by providing a more hydrophobic and flexible environment close to the active site entry. Finally, we constructed a quadruple variant M78F/W82A/I284F/T440Q to generate the most productive substrate conformation. The 1-propiophenone catalytic efficiency of the mutant was enhanced by more than 470-times in terms ofkcat/KM, and the conversion increased from 1.3 to 94.4% compared with that of WT, without any stereoselectivity loss (ee > 99.9%). Meanwhile, the obtained mutant also showed significant activity improvements towards various aryl alkyl ketones with a small substituent larger than the methyl group ranging between 104- and 230-fold, demonstrating great potential for the efficient synthesis of enantiopure aryl alkyl amines with steric hindrance in the small binding pocket.

Preparation of chiral primary amine through asymmetric reductive amination of simple ketone under catalytic action of ruthenium-diphosphine catalyst

The invention relates to a method for preparing chiral primary amine. The method comprises the steps: performing a hydrogenation reductive amination reaction on simple ketone and an ammonium salt RCOONH4 under the action of a ruthenium-chiral diphosphine catalyst, then adding an acid, performing heating for hydrolysis, and adopting a one-pot method to prepare the chiral primary amine. The method has the advantages of good universality of the substrate, high reaction efficiency and the like.

Application of “Smart” Amine Donors for Rapid Screening and Scale-Up of Transaminase-Mediated Biotransformations

The “smart” amine donors o-xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative-scale synthesis of selected compounds using a commercially available amine transaminase, ATA256. The methodology enables both screening and preparative-scale biotransformations to be performed with a single enzyme and simplifies the generation of sp3-rich small-molecule libraries.