220717-72-6

Basic information

• Product Name: 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid
• Synonyms: 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid
• CAS NO: 220717-72-6
• Molecular Weight: 500.576
• Mol File: 220717-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid(220717-72-6)
• EPA Substance Registry System: 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid(220717-72-6)

Safety Data

• Hazardous Substances Data: 220717-72-6(Hazardous Substances Data)

Upstream product

• 220717-60-2 2-((S)-1-{[2-((S)-1-tert-Butoxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester 
• 220717-62-4 2-((S)-1-{[2-((S)-1-Amino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester 
• 220717-54-4 4-<2-<(S)-1-tert-butyloxycarbonylamino-2-methylpropyl>>-oxazole carboxylic acid 
• 158068-94-1 (S)-2-((S)-1-((tert-butoxycarbonyl)amino)-2-methylpropyl)-4,5-dihydrooxazole-4-carboxylic acid methyl ester 
• 220717-59-9 2-<(S)-1-amino-2-methylpropyl>-4-ethoxycarbonylthiazole 
• 158068-97-4 2-<(S)-1--2-methylpropyl>-4-carbomethoxyoxazole 
• 96929-07-6 2-<(S)-1--2-methylpropyl>-4-carbethoxythiazole 
• 96929-02-1 (S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester 
• 220717-71-5 2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carboxylic acid ethyl ester 

Downstream Products

• 220717-73-7 (4S,5R)-2-((S)-1-{[2-((S)-1-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 

Relevant articles and documents

Total synthesis of bistratamide D

The total synthesis of the macrocyclic hexapeptide bistratamide D is reported. The synthetic strategy involved assembly of enantiomerically pure oxazole, thiazole, and oxazoline segments derived from amino acids. Macrocyclization of the hexapeptidic aminooxazoline-oxazole-thiazole carboxylic acid fragment was accomplished by activation with O-(7- azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl-uronium hexafluorophosphate (HATU).