220717-73-7Relevant articles and documents
Total synthesis of bistratamide D
Downing, Susan V.,Aguilar, Enrique,Meyers
, p. 826 - 831 (2007/10/03)
The total synthesis of the macrocyclic hexapeptide bistratamide D is reported. The synthetic strategy involved assembly of enantiomerically pure oxazole, thiazole, and oxazoline segments derived from amino acids. Macrocyclization of the hexapeptidic aminooxazoline-oxazole-thiazole carboxylic acid fragment was accomplished by activation with O-(7- azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl-uronium hexafluorophosphate (HATU).