221176-49-4 Usage
Description
5,10-Dihydro-2-methyl-4H-thieno[2,3-β][1,5]benzodiazepin-4-one (Olanzapine Impurity) is a chemical compound that is identified as an impurity in the synthesis of Olanzapine, a pharmaceutical drug. It is characterized by its yellow solid appearance and is associated with the chemical properties of the Olanzapine molecule.
Uses
Used in Pharmaceutical Industry:
5,10-Dihydro-2-methyl-4H-thieno[2,3-β][1,5]benzodiazepin-4-one (Olanzapine Impurity) is used as a reference material for quality control and analytical purposes in the pharmaceutical industry. It helps in the identification, quantification, and control of impurities in the manufacturing process of Olanzapine, ensuring the purity and safety of the final drug product.
Used in Research and Development:
In the field of research and development, 5,10-Dihydro-2-methyl-4H-thieno[2,3-β][1,5]benzodiazepin-4-one (Olanzapine Impurity) serves as a valuable compound for studying the synthesis, properties, and potential applications of Olanzapine and its related compounds. This can lead to the discovery of new drugs, improved manufacturing processes, and a better understanding of the therapeutic effects of Olanzapine.
Check Digit Verification of cas no
The CAS Registry Mumber 221176-49-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,1,7 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 221176-49:
(8*2)+(7*2)+(6*1)+(5*1)+(4*7)+(3*6)+(2*4)+(1*9)=104
104 % 10 = 4
So 221176-49-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H10N2OS/c1-7-6-8-11(15)13-9-4-2-3-5-10(9)14-12(8)16-7/h2-6,14H,1H3,(H,13,15)
221176-49-4Relevant articles and documents
Reductive Condensation of a Nitro Group with Carboxylic Acids Promoted by Phosphorus(III) Compounds: A Short Route to 5 H -Dibenzo[ b, e ][1,4]diazepin-11(10 H)-ones
Tryniszewski, Micha?,Bujok, Robert,Gańczarczyk, Roman,Wróbel, Zbigniew
, p. 3086 - 3094 (2020/08/10)
Tributyl- or triphenylphosphine promotes a one-pot, three-step method for the synthesis of differently substituted dibenzodiazepinones from N -aryl-2-nitroanilines. Pyridine analogues and the corresponding thiazepinones can also be formed using this method. The process involves deoxygenation of the nitro group, then formation of an iminophosphorane intermediate and its intramolecular condensation with a carboxyl group placed in the N -aryl group. The role of the carboxyl group in the formation of the iminophosphorane and the mode of cyclization are discussed.
A PROCESS FOR THE PREPARATION OF N-DEMETHYLOLANZAPINE
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Page/Page column 6; 7, (2008/06/13)
The invention relates to the process for the preparation of N- demethylolanzapine and the use of N-demethylolanzapine obtained by the process for the preparation of antipsychotic medicament olanzapine. According to the process of the invention the reaction of an- hydrous piperazine with 4-amino-2-methyl-10H-thieno[2.3-b]- [1.5]benzodiazepine or its inorganic acid addition salt is carried out in molten piperazine, in the absence of a solvent.
