221255-77-2

Basic information

• Product Name: (±)-tert-butyl 3-(piperazin-2-yl)propanoate
• Synonyms: (±)-tert-butyl 3-(piperazin-2-yl)propanoate
• CAS NO: 221255-77-2
• Molecular Weight: 214.308
• Mol File: 221255-77-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (±)-tert-butyl 3-(piperazin-2-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-tert-butyl 3-(piperazin-2-yl)propanoate(221255-77-2)
• EPA Substance Registry System: (±)-tert-butyl 3-(piperazin-2-yl)propanoate(221255-77-2)

Safety Data

• Hazardous Substances Data: 221255-77-2(Hazardous Substances Data)

Upstream product

• 109-08-0 2-Methylpyrazine 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 165530-42-7 tert-butyl 3-(pyrazin-2-yl)propanoate 

Downstream Products

• 891782-61-9 3-Piperazin-2-yl-propionic acid 
• 952063-33-1 (±)-tert-butyl 3-[4-(anilinocarbonyl)piperazin-2-yl]propanoate 
• 117810-52-3 2,3,4,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-6-one 

Relevant articles and documents

COMPOUNDS FOR INHIBITING LRRK2 KINASE ACTIVITY

Compounds of Formula (I) or pharmaceutically acceptable salt thereof, a pharmaceutical compositions comprising these compounds, the use of these compounds and compositions in the treatment of diseases in which LRRK-2 kinase is involved.

Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs

Structure-activity relationships on two novel potent cognition enhancing drugs, unifiram (DM232, 1) and sunifiram (DM235, 2), are reported. Although none of the compounds synthesised reached the potency of the parent drugs, some fairly active compounds have been identified that may represent new leads to develop other cognition enhancing drugs. An interesting result of this research is the identification of two compounds (13 and 14) that are endowed with amnesing activity (the opposite of the activity of the original molecules) and are nearly equipotent to scopolamine. Moreover, two compounds of the series (5 and 6) were found endowed with analgesic activity on a rat model of neuropathic pain at the dose of 1 mg/kg.