2213-82-3Relevant articles and documents
Chae et al.
, p. 1207,1208 (1977)
Synthesis of 6-aminobenzopentathiepines by reactions of 4-nitrobenzodithiol-2-ones with NaHS
Khomenko, Tatyana M.,Korchagina, Dina V.,Komarova, Nina I.,Volcho, Konstantin P.,Salakhutdinov, Nariman F.
scheme or table, p. 193 - 197 (2012/04/05)
The reactions of benzodithiol-2-ones containing a 4-nitro group with NaHS led to mixtures of 6- aminobenzopentathiepines and 4-nitrobenzotrithiols. The product ratio and yields depend on the substituent in the aromatic ring. Based on the yields of benzopentathiepines, the following series of substituent efficiency can be inferred: CF3 ? F, Cl > CN. Aminobenzopentathiepines are probably formed via the intermediate benzotrithiols; the transformation apparently starts with the reduction of the nitro group.
Metabolism and disposition of 1,4,7,8-tetrachlorodibenzo-p-dioxin in rats
Huwe,Feil,Larsen,Wiener
, p. 1885 - 1893 (2007/10/03)
Metabolism studies of 1,4,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a relatively nontoxic dioxin congener, were undertaken to gain a better understanding of mammalian metabolism of dioxins without the problems associated with the use of the most toxic congener, 2,3,7,8-TCDD. 14C- 1,4,7,8-TCDD was dosed to conventional and bile-cannulated rats at a level of 8 mg/kg. The 14C was excreted almost entirely in 72 hours with the major routes of excretion feces and bile. Metabolites were identified from the feces, bile, and urine by GC-MS or negative ion FAB MS and 1H NMR. The two major fetal metabolites were hydroxylated tetra- and triCDDs. Glucuronide and sulfate conjugates of these hydroxyl metabolites were found in the urine and bile. Minor metabolites included dichlorocatechol, dihydroxylated tetra- and triCDDs, and conjugates of these compounds.
Electrophilic Aromatic Substitution. Part 34. Nitration of 1-Chloro-4-nitrobenzene, 1,3-Dichloro-2-nitrobenzene, 1,3-Dinitrobenzene, 1-Chloro-2,4-dinitrobenzene, and 2-Chloro-1,3-dinitrobenzene in Sulphuric Acid and Oleum
Melhuish, Martin W.,Moodie, Roy B.,Payne, Malcolm A.,Schofield, Kenneth
, p. 1637 - 1642 (2007/10/02)
Yields of the expected nitro products from 1-chloro-4-nitrobenzene and 1,3-dichloro-2-nitrobenzene nitrated at 25 deg C in sulphuric acid or oleum containing 1 mol dm-3 nitric acid were quantitative.The rate profile for nitration of 1,3-dichloro-2-nitrobenzene is normal, but sulphonation is a competing process when the concentration of nitric acid is low.Kinetics of nitration of 1,3-dinitrobenzene at 150 deg C are reported; yields of 1,3,5-trinitrobenzene, the only detected aromatic product, are low.The title chlorodinitrobenzenes each give, on nitration at 130 deg C, a dichlorodinitrobenzene as well as a chlorotrinitrobenzene.The kinetics and yields of the two products from 1-chloro-2,4-dinitrobenzene under a variety of conditions are reported and discussed in relation to a previously proposed mechanism.