221539-62-4

Basic information

• Product Name: 3-(4-methoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline
• Synonyms: 3-(4-methoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline
• CAS NO: 221539-62-4
• Molecular Weight: 282.299
• Mol File: 221539-62-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline(221539-62-4)
• EPA Substance Registry System: 3-(4-methoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline(221539-62-4)

Safety Data

• Hazardous Substances Data: 221539-62-4(Hazardous Substances Data)

Upstream product

• 221539-30-6 2-amino-N-(4-methoxybenzyl)benzamide 
• 57-13-6 urea 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 824-94-2 p-methoxybenzyl chloride 
• 118-48-9 isatoic anhydride 
• 2393-23-9 4-methoxy-benzylamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 118-92-3 anthranilic acid 
• 56651-60-6 4-methoxybenzyl isocyanate 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 221539-88-4 1-(4-bromobutyl)-2,4-dioxo-3-(4-methoxybenzyl)-1,2,3,4-tetrahydroquinazoline 
• 221539-87-3 1-(5-chloropentyl)-2,4-dioxo-3-(4-methoxybenzyl)-1,2,3,4-tetrahydroquinazoline 
• 112733-34-3 2-[1,2,3,4-Tetrahydro-3-(4-methoxybenzyl)-2,4-dioxoquinazolin-1-yl]acetic acid 
• 128650-87-3 <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid 
• 112732-92-0 Ethyl 2-[1,2,3,4-tetrahydro-3-(4-methoxybenzyl)-2,4-dioxoquinazolin-1-yl]acetate 

Relevant articles and documents

One-pot Syntheses of Some New 2,4(1H,3H)-quinazolinedione Derivatives in the Absence of Catalyst

A facile, rapid and one-pot procedure for the synthesis of some new 2,4(1H,3H)-quinazolinediones is described. The method involves the one-pot condensation of isatoic anhydride, primary amine and carbonyl diimidazole (CDI) in the absence of organic or inorganic catalyst. It affords the corresponding product in high yield.

Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst

Regioselective C-H oxidation of aliphatic molecules with synthetic catalysts is challenging. We incorporated substrate-recognition sites into a ruthenium porphyrin-heteroaromatic N-oxide catalytic system in order to characterise its regioselectivity for t

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

A simple and efficient synthetic method for the preparation of quinazoline type phosphodiesterase 7 (PDE7) inhibitors, based on microwave irradiation, has been developed. The use of this methodology improved yields and reaction times, providing a scalable procedure. These compounds are pharmacologically interesting because of their in vivo efficacy both in spinal cord injury and Parkinson's disease models, as shown in previous studies from our group. Herein we describe for the first time that administration of one of the PDE7 inhibitors here optimized, 3-phenyl-2,4-dithioxo-1,2,3,4-tetrahydroquinazoline (compound 5), ameliorated brain damage and improved behavioral outcome in a permanent middle cerebral artery occlusion (pMCAO) stroke model. Furthermore, we demonstrate that these PDE7 inhibitors are potent anti-inflammatory as well as neuroprotective agents in primary cultures of neural cells. These results led us to propose PDE7 inhibitors as a new class of therapeutic agents for neuroprotection.