56651-60-6 Usage
Description
4-Methoxybenzyl isocyanate (PMBNCO), also known as p-methoxybenzyl isocyanate, is an organic building block that features an isocyanate group. It is characterized by its clear, colorless to yellow liquid appearance and has been studied for its enthalpy of vaporization at boiling point.
Uses
Used in Pharmaceutical Synthesis:
4-Methoxybenzyl isocyanate is used as a synthetic intermediate for the creation of various pharmaceutical compounds. Its application is particularly relevant in the synthesis of:
1. 1-(4-methoxybenzyl)-3-2-[(4-nitrophenyl)amino]ethylurea
2. 1-(4-methoxybenzyl)-3-2-[(5-nitropyridin-2-yl)amino]ethylurea
These compounds are valuable in the development of new drugs and therapies.
Used in Organic Chemistry:
In the field of organic chemistry, 4-Methoxybenzyl isocyanate serves as a key component in the multi-step synthesis of complex molecules, such as:
2. 2-deoxy-2-ureido-D-ribo-hexulofuranosonamide
3. Bicyclic guanidine core of batzelladine A
These synthesized products have potential applications in various industries, including pharmaceuticals, materials science, and chemical research.
Check Digit Verification of cas no
The CAS Registry Mumber 56651-60-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,6,5 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 56651-60:
(7*5)+(6*6)+(5*6)+(4*5)+(3*1)+(2*6)+(1*0)=136
136 % 10 = 6
So 56651-60-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO2/c1-12-9-4-2-8(3-5-9)6-10-7-11/h2-5H,6H2,1H3
56651-60-6Relevant articles and documents
A Synthetic Strategy for Saxitoxin Skeleton by a Cascade Bromocyclization: Total Synthesis of (+)-Decarbamoyl-α-saxitoxinol
Ueno, Sohei,Nakazaki, Atsuo,Nishikawa, Toshio
, p. 6368 - 6371 (2016)
A new synthetic strategy for the formation of the ABC tricyclic framework of saxitoxin was developed. The BC ring moiety, including a spiro-aminal structure, was first constructed stereoselectively by a newly designed cascade bromocyclization of a readily available internal alkyne bearing guanidine and urea. The A ring was then synthesized by a guanylation of a cyclic urea, easily prepared via the oxidative cleavage of the diol of the cascade product, followed by addition of cyanide. This strategy enables the concise stereocontrolled total synthesis of (+)-decarbamoyl-α-saxitoxinol, which is a naturally occurring saxitoxin analogue.
NOVEL CYCLICSULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION
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Page/Page column 19; 26, (2018/05/24)
The present invention relates to compounds of formula (I), wherein R1, R2 and R3 and n are as described herein, or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
BICYCLIC PESTICIDAL COMPOUNDS
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Page/Page column 65, (2018/12/13)
The present invention relates to compounds of formula (I), wherein the variables are defined as given in the description and claims. The invention further relates to uses, processes and composition for compounds (I).