2219-12-7

Basic information

• Product Name: 2-(1-methyl-1H-benzimidazol-2-yl)phenol
• Synonyms: 2-(1-methyl-1H-benzimidazol-2-yl)phenol;1-Methyl-2-(2-hydroxyphenyl)-1H-benzimidazole;2-(2-Hydroxyphenyl)-1-methyl-1H-benzoimidazole
• CAS NO: 2219-12-7
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.25788
• EINECS: 218-725-8
• Mol File: 2219-12-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 379.5°Cat760mmHg
• Flash Point: 183.3°C
• Appearance: /
• Density: 1.259g/cm³
• Vapor Pressure: 5.81E-06mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 2-(1-methyl-1H-benzimidazol-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-methyl-1H-benzimidazol-2-yl)phenol(2219-12-7)
• EPA Substance Registry System: 2-(1-methyl-1H-benzimidazol-2-yl)phenol(2219-12-7)

Safety Data

• Hazardous Substances Data: 2219-12-7(Hazardous Substances Data)

Usage

Class

Benzimidazole derivatives

Pharmacological activities

Potential anti-tumor effects, cancer cell growth inhibition, possible treatment for neurological disorders and infectious diseases

Molecular pathways

Targets specific molecular pathways to inhibit cancer cell growth

Ongoing research

Further studies are being conducted to understand its biological activities and potential therapeutic applications.

InChI:InChI=1/C14H12N2O/c1-16-12-8-4-3-7-11(12)15-14(16)10-6-2-5-9-13(10)17/h2-9,15H,1H3/b14-10-

Upstream product

• 64908-64-1 2-phenoxyisoindol-1,3-dione 
• 98-80-6 phenylboronic acid 
• 1632-83-3 1-Methylbenzimidazole 
• 5661-50-7 N-(phenoxy)acetamide 
• 108-95-2 phenol 
• 4846-21-3 O-phenylhydroxylamine 
• 1354644-36-2 N-(2-allyloxybenzylidene)-N'-methyl-N'-phenylbenzene-1,2-diamine 
• 28752-82-1 2-(allyloxy)benzaldehyde 
• 50374-92-0 N¹-methyl-N¹-phenylbenzene-1,2-diamine 
• 4760-34-3 N-methyl-1,2-phenylenediamine 
• 69-72-7 salicylic acid 
• 90-02-8 salicylaldehyde 
• 110881-34-0 N-methyl-N'-salicylidene-o-phenylenediamine 
• 155228-12-9 1-methoxy-2-(1-methyl-1H-benzimidazol-2-yl)benzene 

Relevant articles and documents

Rhodium(III)-Catalyzed ortho-Heteroarylation of Phenols through Internal Oxidative C-H Activation: Rapid Screening of Single-Molecular White-Light-Emitting Materials

Reported herein is the first example of a transition-metal-catalyzed internal oxidative C-H/C-H cross-coupling between two (hetero)arenes through a traceless oxidation directing strategy. Without the requirement of an external metal oxidant, a wide range of phenols, including phenol-containing natural products, can undergo the coupling with azoles to assemble a large library of highly functionalized 2-(2-hydroxyphenyl)azoles. The route provides an opportunity to rapidly screen white-light-emitting materials. As illustrative examples, two bis(triphenylamine)-bearing 2-(2-hydroxyphenyl)oxazoles, which are difficult to access otherwise, exhibit bright white-light emission, high quantum yield, and thermal stability. Also presented is the first example of the white-light emission, in a single excited-state intramolecular proton transfer system, of 2-(2-hydroxyphenyl)azoles, thus highlighting the charm of C-H activation in the discovery of new organic optoelectronic materials.

Compound with heterocyclic ligand and preparation method and application thereof

The invention provides a compound with a heterocyclic ligand and a preparation method and application thereof. According to the compound with the heterocyclic ligand, the specific heterocyclic ligand is selected to be combined with metal aluminum, so that after the obtained organic compound is applied to an organic light-emitting device, the light-emitting efficiency of the device is improved, and the service life is long.

Gas-phase generation and cyclisation reactions of imidoyl radicals

Some 1,2-diarylimidoyl radicals were generated in the gas-phase by intramolecular radical translocation from ortho-imino-aryloxyl radicals, in turn generated under flash vacuum pyrolysis (FVP) conditions. The imidoyls reacted with XR ortho′-substituents in the N-aryl group to give (in most cases) modest yields of cyclisation products. Depending on the nature of the bridging atom (X), the formation of these products was initiated either by a further hydrogen atom translocation (X = CH2), or by ipso-attack onto the aryl group (R = Ph), or by direct substitution at the heteroatom (X = S). With XR = N(Me)Ph, the major reaction product was probably the result of a competing pathway not involving the corresponding imidoyl.