50374-92-0

Basic information

• Product Name: N-(2-aminophenyl)-N-methyl-N-phenylamine
• Synonyms: N-(2-aminophenyl)-N-methyl-N-phenylamine;N-METHYL-N-PHENYL-1,2-BENZENEDIAMINE;OTAVA-BB 1179961;N1-methyl-N1-phenylbenzene-1,2-diamine;2-N-methyl-2-N-phenylbenzene-1,2-diamine
• CAS NO: 50374-92-0
• Molecular Formula: C₁₃H₁₄N₂
• Molecular Weight: 198.268
• Mol File: 50374-92-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 339.812°C at 760 mmHg
• Flash Point: 140.731°C
• Appearance: /
• Density: 1.125g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.653
• PKA: 4.19±0.10(Predicted)
• CAS DataBase Reference: N-(2-aminophenyl)-N-methyl-N-phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-aminophenyl)-N-methyl-N-phenylamine(50374-92-0)
• EPA Substance Registry System: N-(2-aminophenyl)-N-methyl-N-phenylamine(50374-92-0)

Safety Data

• Hazardous Substances Data: 50374-92-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H14N2/c1-15(11-7-3-2-4-8-11)13-10-6-5-9-12(13)14/h2-10H,14H2,1H3

Upstream product

• 17763-67-6 Phenyl triflate 
• 100-61-8 N-methylaniline 
• 108-86-1 bromobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 88-74-4 2-nitro-aniline 
• 62-53-3 aniline 
• 119-75-5 2-nitro-N-phenylaniline 
• 52997-62-3 2-nitro-N-methyl-N-phenylaniline 

Downstream Products

• 1429049-04-6 N¹-methyl-N²-(2-nitrophenyl)-N¹-phenylbenzene-1,2-diamine 
• 1429049-14-8 N¹-(2-aminophenyl)-N¹-butyl-N²-methyl-N²-phenylbenzene-1,2-diamine 
• 1429049-11-5 N¹-(2-aminophenyl)-N¹,N²-dimethyl-N²-phenylbenzene-1,2-diamine 
• 1429049-18-2 N¹-(2-(butylamino)phenyl)-N²-methyl-N²-phenylbenzene-1,2-diamine  
• 1429049-17-1 N¹-methyl-N²-(2-(methylamino)phenyl)-N¹-phenylbenzene-1,2-diamine  
• 1429049-09-1 N¹-butyl-N²-methyl-N¹-(2-nitrophenyl)-N²-phenylbenzene-1,2-diamine 
• 1429049-06-8 N¹,N²-dimethyl-N¹-(2-nitrophenyl)-N²-phenylbenzene-1,2-diamine  
• 2622-63-1 1-methyl-2-phenylbenzimidazole 
• 2219-12-7 2-(1-methyl-1H-benzo[d]imidazol-2-yl)phenol 
• 94212-05-2 2-(1-phenyl-1H-benzo[d]imidazole-2-yl)phenol 
• 1354644-36-2 N-(2-allyloxybenzylidene)-N'-methyl-N'-phenylbenzene-1,2-diamine 
• 92245-11-9 N-Methyl-o-formamido-diphenylamin 
• 2622-67-5 1,2-diphenyl-1H-benzoimidazole 
• 1484-12-4 N-methylcarbazole 

Relevant articles and documents

1,2-Difunctionalization of Aryl Triflates: A Direct and Modular Access to Diversely Functionalized Anilines

ortho-Amino difunctionalization of aryl triflates has been achieved via a three-component reaction. The cascade reaction proceeds through a zincate base-mediated deprotonative formation of a reactive aryne intermediate, in situ nucleophilic addition, and coupling with electrophilic partners. This strategy leverages the advantageous reactivity of organozincate intermediates, enabling the installation of various functionalities such as amine, azide, oxygen, sulfur, halide, alkynyl, aryl, vinyl, and alkyl groups in a modular manner for the synthesis of diverse aniline skeletons.

COMPOUND

There is provided a compound having Formula (I) wherein each of R1, R2, R4, R5, R6 and R7 are independently selected from (a) H, (b) R17, -OC(R17)3, -OCH(R17)2, -(OCH2R)17, -C(R17)3, -CH(R17)2, or -CH2R17 wherein R17 is a halogen; (c) -CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) -SO2-alkyl; and (n) -N(R11)C(O)R13; wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl ; each of rings A and B are selected from five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring; X is an optional group selected from O, S, S=O, S(=O)2, C=O, S(=O)2NR8, C=ONR9, NR10, wherein R8, R9 and R10 are independently selected from H and hydrocarbyl, wherein n and p are independently selected from O and 1 ; Y is (R11)1-3 wherein each R11 is independently selected from NR12, CR13R14, S(=O)2 and C=O, wherein R12, R13 and R14 are independently selected from H and hydrocarbyl; Z is selected from (i) six or seven membered ring containing carbon and at least one nitrogen, which may be optionally substituted wherein the substituents may together form further ring fused thereto; and (ii) a -R15-NR16- group wherein R15 is an optionally substituted C1-6 alkyl chain and R16 is selected from H and hydrocarbyl; and R3 is selected from Formula (A).

11-(Tetrahydro-3 and 4-pyridinyl)dibenzo[b,e][1,4]diazepines undergo novel rearrangements on treatment with concentrated HBr

11-(1,2,5,6-Tetrahydro-1-methyl-3-pyridinyl)-5-methyl-5H-dibenzo[b,e][1,4] diazepine on heating in conc. HBr afforded trans-5-(2-aminophenyl)-1,3,4,4a,5,10a-hexahydro-2-methylbenzo[b][1,6] naphthyridin-10(2H)-one in one step. The isomer 11-(1,2,5,6-tetrahydro-1-methyl-4-pyridinyl)-5-methyl-5H-dibenzo[b,e][1,4] diazepine underwent a novel rearrangement resulting in the pentacycle, 4-amino-5,13-diaza-13-methyl-bicyclo[3.3.1]nonan[6,7,8-k,l]acridine.