22202-68-2 Usage
Description
ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT, also known as α-ketoglutaric acid sodium salt, is an organic compound that serves as an essential intermediate in the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle. It is a sodium salt of α-ketoglutaric acid, which is a key player in cellular respiration and energy production. ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT has various applications in different industries due to its unique properties and functions.
Uses
Used in Pharmaceutical Industry:
ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT is used as a reagent for the human kynurenine amino transferase II (KAT II) inhibition spectra assay. This application is crucial in the research and development of drugs targeting KAT II, an enzyme involved in the breakdown of tryptophan, which is linked to various neurological and psychiatric disorders.
In the pharmaceutical industry, ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT plays a significant role in the development of drugs that can potentially treat conditions related to the dysregulation of the kynurenine pathway. By serving as a reagent in the KAT II inhibition assay, it helps researchers understand the enzyme's function and develop targeted therapies for various diseases.
Additionally, ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT may have other applications in different industries, such as in the field of biochemistry for studying metabolic pathways or in the development of diagnostic tools. However, the provided materials only mention its use in the pharmaceutical industry for the KAT II inhibition assay. Further research and information would be required to explore its potential uses in other industries.
Biochem/physiol Actions
α-Ketoglutaric acid is the precursor for L-glutamic acid.
Check Digit Verification of cas no
The CAS Registry Mumber 22202-68-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,0 and 2 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 22202-68:
(7*2)+(6*2)+(5*2)+(4*0)+(3*2)+(2*6)+(1*8)=62
62 % 10 = 2
So 22202-68-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H6O5.Na/c6-3(5(9)10)1-2-4(7)8;/h1-2H2,(H,7,8)(H,9,10);/q;+1/p-2
22202-68-2Relevant articles and documents
Chemical transformations of pyridoxal and pyridoxal 5′-phosphate condensation products with amino acids
Pishchugin,Tuleberdiev
, p. 1225 - 1229 (2008/12/22)
The mechanism of chemical transformations of pyridoxal and pyridoxal 5′-phosphate condensation products with amino acids is studied by kinetic measurements. The Schiff bases are shown to be fairly stable in neutral media. In acid media, the Schiff bases a
Some properties of glycine aminotransferase purified from Rhodopseudomonas palustris No. 7 concerning extracellular porphyrin production.
Yamaguchi, Hidetoshi,Ohtani, Masahiro,Amachi, Seigo,Shinoyama, Hirofumi,Fujii, Takaaki
, p. 783 - 789 (2007/10/03)
Glycine aminotransferase (EC 2.6.1.4; GlyAT) was presumed to be an enzyme concerning the supply of glycine for the extracellular porphyrin production by Rhodopseudomonas palustris No. 7. GlyAT was purified from strain No. 7 as an electrophoretically homogenous protein. The enzyme was a monomer protein with the molecular weight of about 42,000. From the absorption spectrum of the enzyme (350 nm, 410 nm), it was indicated that the enzyme had pyridoxal phosphate as a prosthetic group. The enzyme showed high substrate specificity for glutamate as an amino group donor. Apparent Kms for glutamate and glyoxylate were 6.20 mM and 3.75 mM, respectively. The Vmax and Kcat for glutamate were 66.8 mumol/min/mg protein and 46.8 s-1, respectively. The Vmax and Kcat for glyoxylate were 68.8 mumol/min/mg protein and 48.2 s-1. The optimum temperature and pH were 40-45 degrees C and 7.0-7.5, respectively. The enzyme activity lowered to about 50% in the presence of 15 mM ammonium chloride.
