22265-78-7

Basic information

• Product Name: 1-(4-ETHYLPHENYL)-2-THIOUREA
• Synonyms: 1-(4-ETHYLPHENYL)-2-THIOUREA;N-(4-ETHYLPHENYL)THIOUREA
• CAS NO: 22265-78-7
• Molecular Formula: C₉H₁₂N₂S
• Molecular Weight: 180.27
• Mol File: 22265-78-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 294.8 °C at 760 mmHg
• Flash Point: 132.1 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 0.00158mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: 1-(4-ETHYLPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ETHYLPHENYL)-2-THIOUREA(22265-78-7)
• EPA Substance Registry System: 1-(4-ETHYLPHENYL)-2-THIOUREA(22265-78-7)

Safety Data

• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 22265-78-7(Hazardous Substances Data)

Usage

General Description

1-(4-ethylphenyl)-2-thiourea is a chemical compound with the molecular formula C9H12N2S. It is a thiourea derivative with a substituted phenyl group, containing an ethyl group at the para position. 1-(4-ETHYLPHENYL)-2-THIOUREA is widely used in organic synthesis and pharmaceutical research, often serving as a versatile building block for the preparation of various heterocyclic compounds and medicinal agents. It exhibits potential antifungal and antibacterial properties, making it a valuable tool in the development of new pharmaceuticals. Additionally, 1-(4-ethylphenyl)-2-thiourea has been investigated for its potential use in agricultural applications, as it has shown promise as a plant growth regulator and pesticide.

InChI:InChI=1/C9H12N2S/c1-2-7-3-5-8(6-4-7)11-9(10)12/h3-6H,2H2,1H3,(H3,10,11,12)

Upstream product

• 589-16-2 4-aminoethylbenzene 
• 117174-72-8 1-Benzoyl-3-(4-ethyl-phenyl)-thiourea 
• 1147550-11-5 ammonium thiocyanate 
• 18856-63-8 (4-ethylphenyl)isothiocyanate 

Downstream Products

• 1417159-81-9 C₁₆H₁₄N₂O₂S 
• 1390616-74-6 5-(4-methoxybenzylidene)-2-(6-ethylbenzo[d]thiazol-2-ylimino)thiazolidin-4-one 
• 1390616-73-5 5-(4-nitrobenzylidene)-2-(6-ethylbenzo[d]thiazol-2-ylimino)thiazolidin-4-one 
• 1390616-72-4 5-(4-chlorobenzylidene)-2-(6-ethylbenzo[d]thiazol-2-ylimino)thiazolidin-4-one 
• 1329122-52-2 2-(4-ethylphenyl)amino-4-(6-methylimidazo[2,1-b]thiazol-5-yl)-thiazole monohydrobromide 
• 21224-17-9 6-ethyl-3H-benzothiazole-2-thione 
• 88352-27-6 2-S-Methyl-1-(4-ethylphenyl)-5-(2-furfuryl)isodithiobiuret 
• 88352-14-1 2-S-Methyl-1-(4-ethylphenyl)-5-(2-pyridyl)isodithiobiuret 
• 119125-66-5 N-(4-Ethyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 159091-72-2 (4,5-dihydro-thiazol-2-yl)-(4-ethyl-phenyl)-amine 
• 119125-45-0 1-(4-Ethyl-phenyl)-2-methyl-isothiourea; hydriodide 
• 88352-37-8 N-(4-Ethylphenyl)-S-methyl isothiourea 
• 119125-45-0 1-(4-Ethyl-phenyl)-2-methyl-isothiourea; hydriodide 
• 154371-13-8 2-(4-Ethyl-phenylamino)-1-thia-3,9,10-triaza-anthracen-4-one 

Relevant articles and documents

Design, synthesis, and antipoliferative activities of novel substituted imidazole-thione linked benzotriazole derivatives

A new series of benzotriazole moiety bearing substituted imidazol-2-thiones at N1 has been designed, synthesized and evaluated for in vitro anticancer activity against the different cancer cell lines MCF-7(breast cancer), HL-60 (Human promyelocytic leukemia), and HCT-116 (colon cancer). Most of the benzotriazole analogues exhibited promising antiproliferative activity against tested cancer cell lines. Among all the synthesized compounds, BI9 showed potent activity against the cancer cell lines such as MCF-7, HL-60 and HCT-116 with IC50 3.57, 0.40 and 2.63 μM, respectively. Compound BI9 was taken up for elaborate biological studies and the HL-60 cells in the cell cycle were arrested in G2/M phase. Compound BI9 showed remarkable inhibition of tubulin polymerization with the colchicine binding site of tubulin. In addition, compound BI9 promoted apoptosis by regulating the expression of pro-apoptotic protein BAX and anti-apoptotic proteins Bcl-2. These results provide guidance for further rational development of potent tubulin polymerization inhibitors for the treatment of cancer.

Synthesis of substituted benzo[d]thiazol-2-ylcarbamates as potential anticonvulsants

A series of substituted benzo[d]thiazol-2-ylcarbamates 4a-g and 5a-g were synthesized and evaluated for anticonvulsant activity. The structures of the synthesized compounds were confirmed on the basis of their physical and spectral data. The compounds were evaluated for anticonvulsant activity using PTZ-induced convulsion and maximal electroshock models. The target compounds have shown significant activity in these models.

HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS

Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.