223104-29-8 Usage
Description
SEA-0400 is a selective inhibitor of the Na+/Ca2+ exchanger, which is a protein that helps regulate the balance of sodium and calcium ions within cells. It has been shown to be effective in inhibiting Na+-dependent Ca2+ uptake in various cell lines, including rat astrocyte, microglia, and cortical neuron cell lines. Additionally, SEA-0400 has demonstrated potential therapeutic benefits in preventing dopaminergic neurotoxicity in a mouse model of Parkinson's disease and in reducing reperfusion injury in cerebral ischemic models.
Uses
Used in Pharmaceutical Industry:
SEA-0400 is used as a therapeutic agent for the treatment of neurological disorders, particularly Parkinson's disease. Its ability to prevent dopaminergic neurotoxicity makes it a promising candidate for the development of new treatments for this condition.
Used in Cardiology:
SEA-0400 is used as a protective agent in the context of reperfusion injury, which can occur during and after procedures such as heart attacks or strokes. By attenuating reperfusion injury, SEA-0400 may help to reduce the severity of tissue damage and improve patient outcomes.
Used in Research:
SEA-0400 is used as a research tool for studying the role of the Na+/Ca2+ exchanger in various cellular processes. Its high selectivity for this exchanger makes it a valuable compound for investigating the molecular mechanisms underlying ion transport and cellular signaling.
Check Digit Verification of cas no
The CAS Registry Mumber 223104-29-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,1,0 and 4 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 223104-29:
(8*2)+(7*2)+(6*3)+(5*1)+(4*0)+(3*4)+(2*2)+(1*9)=78
78 % 10 = 8
So 223104-29-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3
