223464-67-3

Basic information

• Product Name: (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide
• Synonyms: (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide
• CAS NO: 223464-67-3
• Molecular Weight: 156.108
• Mol File: 223464-67-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide(223464-67-3)
• EPA Substance Registry System: (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide(223464-67-3)

Safety Data

• Hazardous Substances Data: 223464-67-3(Hazardous Substances Data)

Upstream product

• 122008-12-2 3,3,3-trifluoro-2-amino-2-methylpropionamide 

Relevant articles and documents

The substrate specificity of the heat-stable stereospecific amidase from Klebsiella oxytoca

The substrate specificity of the heat-stable stereospecific amidase from Klebsiella oxytoca was investigated. In addition to the original substrate, 3,3,3-trifluoro-2-hydroxy-2-methylpropanamide, the amidase accepted 2-hydroxy-2-(trifluoromethyl)-butanamide and 3,3,3-trifluoro-2-amino-2- methylpropanamide as substrates. Compounds with larger side chains and compounds where the hydroxyl group was substituted with a methoxy group, or in which the CF3 group was substituted by CCl3, were not accepted. The biotransformation is a new synthetic route to (R)-(+)-3,3,3- trifluoro-2-amino-2-methylpropanoic acid, and its related (S)-(-)-amide, and to (R)-(+)-2-hydroxy-2-(trifluoromethyl)-butanoic acid and its related (S)-(-)-amide.

Enzymatic resolution of Cα-fluoroalkyl substituted amino acids

A methodology for the enzymatic resolution of sterically constrained C α-fluoroalkyl substituted amino acids has been developed. Racemic H-(αTfm)Ala-NH2, H-(αCF2Cl)Ala-NH 2 and H-(αCF2Br)Ala-NH2