2235-46-3 Usage
Description
N,N-Diethylacetoacetamide is a β-dicarbonyl compound that exists as a clear yellow liquid. It is an important intermediate in the synthesis of various chemicals and pharmaceuticals due to its unique chemical properties.
Uses
Used in Insecticide Industry:
N,N-Diethylacetoacetamide is used as an intermediate for the manufacture of insecticides, specifically phosphamidon. Phosphamidon is an organophosphate insecticide that acts as a cholinesterase inhibitor, making it effective in controlling and eliminating insect pests.
Used in Pharmaceutical Industry:
N,N-Diethylacetoacetamide is utilized as an intermediate in the synthesis of potent calcium channel blockers. These blockers include 2,6,6-trimethyl-3-diethylaminocarbonyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives and N,N-diethyl-2,6,6-trimethyl-4-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide. These compounds are essential in the treatment of various cardiovascular diseases.
Used in Chemical Synthesis:
N,N-Diethylacetoacetamide can undergo Michael addition in the presence of a bis(2,4-pentanedionato)nickel(II) catalyst. This reaction is crucial in the synthesis of various organic compounds, further expanding the utility of N,N-Diethylacetoacetamide in the chemical industry.
Flammability and Explosibility
Flammable
Check Digit Verification of cas no
The CAS Registry Mumber 2235-46-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,3 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2235-46:
(6*2)+(5*2)+(4*3)+(3*5)+(2*4)+(1*6)=63
63 % 10 = 3
So 2235-46-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H15NO2/c1-4-9(5-2)8(11)6-7(3)10/h4-6H2,1-3H3
2235-46-3Relevant articles and documents
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Horder,J.R.,Lappert,M.F.
, p. 485 - 486 (1967)
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NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS
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Paragraph 0194; 0196, (2019/05/16)
The present invention relates to novel dihydropyridine derivatives of formula (I): as modulators of nuclear receptors selected from androgen receptor and glucocorticoid receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of androgen receptor and/or glucocorticoid receptor, selected from cancer, metastasizing cancers, benign prostate hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting diseases, cachexia, Cushing's syndrome, anti-psychotic drug induced weight gain, obesity, post-traumatic stress disorder and alcoholism.
O -Iodoxybenzoic Acid (IBX)-Iodine Mediated One-Pot Deacylative Sulfonylation of 1,3-Dicarbonyl Compounds: A Synthesis of β-Carbonyl Sulfones
Katrun, Praewpan,Songsichan, Teerawat,Soorukram, Darunee,Pohmakotr, Manat,Reutrakul, Vichai,Kuhakarn, Chutima
supporting information, p. 1109 - 1121 (2017/02/24)
A combination of o-iodoxybenzoic acid (IBX) and a catalytic amount of iodine is found to promote a facile one-pot deacylative sulfonylation reaction of 1,3-dicarbonyl compounds with sodium sulfinates to yield β-carbonyl sulfones. The present method provides the target products bearing a wide variety of functional groups in one step and in good yields.
