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22414-26-2

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22414-26-2 Usage

General Description

2-Phenyl-propionyl chloride, depicted by the molecular formula C9H9ClO, is a chemical compound that belongs to the class of organic compounds known as cinnamic acid derivatives. It is characterized by a cinnamic acid moiety, which is itself derived from phenylalanine. It is commonly used as a reagent in various organic synthesis processes, such as the formation of amides and esters. 2-Phenyl-propionyl chloride is known to be a clear to pale yellow liquid, with a melting point of -75 degrees Celsius and a boiling point of 247 degrees Celsius. It should be handled with care as it can cause burns and other serious health hazards if it comes into contact with skin or eyes. Its use should always be in a controlled environment following safety protocols.

Check Digit Verification of cas no

The CAS Registry Mumber 22414-26-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,4,1 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 22414-26:
(7*2)+(6*2)+(5*4)+(4*1)+(3*4)+(2*2)+(1*6)=72
72 % 10 = 2
So 22414-26-2 is a valid CAS Registry Number.

22414-26-2 Well-known Company Product Price

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  • Aldrich

  • (689548)  2-Phenylpropionylchloride  ≥95%

  • 22414-26-2

  • 689548-1G

  • 769.86CNY

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22414-26-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Phenylpropanoyl chloride

1.2 Other means of identification

Product number -
Other names 2-phenylpropionic acid chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22414-26-2 SDS

22414-26-2Relevant articles and documents

The Structure of Fortesol, a Novel Fused Tricyclic Alcohol Used for Resolution of Phosphinic and Carboxylic Acids

Fortes, Antonio G.,Johnstone, Robert A. W.,Whittaker, David,Lewis, Norman J.

, p. 5836 - 5837 (1994)

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Structures and ambident reactivities of azolium enolates

Maji, Biplab,Mayr, Herbert

, p. 11163 - 11167 (2013)

Oxygen versus carbon: Azolium enolates were generated by the reactions of N-heterocyclic carbenes (NHCs) with methyl phenyl ketene and characterized by X-ray crystallography. Kinetic studies show that the enolate oxygen is 20 times more nucleophilic than

Synthesis and in vitro anti-platelet aggregation activities of 2-methoxy-5-arylamido-N-(pyridin-3-yl-methyl)benzamides

Wang, Yan,Wang, Xiao,Chen, Xin,Liu, Xiujie

, (2019)

In order to discover novel compounds with anti-platelet aggregation activities, a series of novel 2-methoxy-5-arylamido-N-(pyridin-3-ylmethyl)benzamides (1a–n) were synthesized and their anti-platelet aggregation activities were evaluated by the turbidimetric method in response to the following agonists: adenosine diphosphate (ADP) (5 mM/L), arachidonic acid (AA) (20 μM/L), and collagen (1 mg/mL). Those synthesized compounds that have better in vitro activities were subjected to cell toxicity tests via cell counting kit-8 (CCK-8) assay. The biological evaluation revealed that compound 1a (IC50: 0.21 μM/L) exhibited the highest anti-platelet aggregation activities when ADP was selected as an inducer, and compound 1b (IC50: 0.23 μM/L) showed the best activities when AA was selected as inducer, and compound 1m (inhibition rate: 55.06%) had significant anti-platelet aggregation activities when collagen was selected as inducer among all target compounds. Moreover, the effect of cell toxicity exhibited that none of the compounds had obvious cell toxicity against L929 cells. Therefore, 2-methoxy-5-arylamido-N-(pyridin-3-ylmethyl)benzamides have the potential to become a novel kind of anti-platelet drugs and deserve further study.

ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF

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Paragraph 0067, (2021/11/04)

Provided are an acylamino bridged heterocyclic compound of formula (I) or a pharmaceutically acceptable salt, an isomer, a solvate, a crystal, or a prodrug thereof, and a pharmaceutical composition comprising the compound, and an application of the compou

One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles

Bobal, Pavel,Otevrel, Jan,Svestka, David

, p. 25029 - 25045 (2020/07/14)

We have identified a novel one-pot method for the synthesis of β-amino alcohols, which is based on C-H bond hydroxylation at the benzylic α-carbon atom with a subsequent nitrile or amide functional group reduction. This cascade process uses molecular oxygen as an oxidant and sodium bis(2-methoxyethoxy)aluminum hydride as a reductant. The substrate scope was examined on 30 entries and, although the respective products were provided in moderate yields only, the above simple protocol may serve as a direct and powerful entry to the sterically congested 1,2-amino alcohols that are difficult to prepare by other routes. The plausible mechanistic rationale for the observed results is given and the reaction was applied to a synthesis of a potentially bioactive target. This journal is

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