31508-44-8

Basic information

• Product Name: R,S-2-Phenyl-propionicacidmethylester
• Synonyms: R,S-2-Phenyl-propionicacidmethylester;methyl 2-phenylpropionate;2-PHENYLPROPANOIC ACID METHYL ESTER;(2S)-2-Phenylpropionic acid methyl ester;(S)-2-Phenylpropionic acid methyl ester;[S,(+)]-2-Phenylpropionic acid methyl ester;(2R)-2-Phenylpropionic acid methyl ester;(R)-2-Phenylpropionic acid methyl ester
• CAS NO: 31508-44-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• EINECS: 250-667-9
• Mol File: 31508-44-8.mol
• Article Data: 242

Chemical Properties

• Boiling Point: 212.3°Cat760mmHg
• Flash Point: 89.3°C
• Appearance: /
• Density: 1.029g/cm³
• Vapor Pressure: 0.174mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: R,S-2-Phenyl-propionicacidmethylester(CAS DataBase Reference)
• NIST Chemistry Reference: R,S-2-Phenyl-propionicacidmethylester(31508-44-8)
• EPA Substance Registry System: R,S-2-Phenyl-propionicacidmethylester(31508-44-8)

Safety Data

• Hazardous Substances Data: 31508-44-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 43, p. 2170, 1978 DOI: 10.1021/jo00405a019Synthesis, p. 880, 1979 DOI: 10.1055/s-1979-28857Tetrahedron Letters, 30, p. 371, 1989 DOI: 10.1016/S0040-4039(00)95205-5

InChI:InChI=1/C10H12O2/c1-8(10(11)12-2)9-6-4-3-5-7-9/h3-8H,1-2H3

Upstream product

• 101-41-7 benzeneacetic acid methyl ester 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 
• 492-37-5 hydratropic acid 
• 67-56-1 methanol 
• 51816-21-8 2-(2-phenylethyl)-Δ²-oxazoline 
• 34713-70-7 2-Phenylpropanal 
• 90-87-9 2-phenylpropionaldehyde dimethyl acetal 
• 109-72-8 n-butyllithium 
• 67863-40-5 lithium isopropenolate 
• 3156-07-8 methyl phenyl ketene 
• 2042-85-5 1,2-diphenylpropan-1-one 
• 616-38-6 carbonic acid dimethyl ester 
• 492-38-6 2-phenylacrylic acid 

Downstream Products

• 28645-07-0 (S)-methyl 2-phenylpropanoate 
• 2328-26-9 methyl (R)-2-phenylpropanoate 
• 124658-21-5 Methyl α-fluoro-α-methylbenzeneacetate 
• 117606-78-7 (S)-2-Methyl-3-oxo-2-phenyl-hexanoic acid methyl ester 
• 492-37-5 hydratropic acid 
• 7782-24-3 (S)-2-Phenylpropionic acid 
• 7782-26-5 (R)-2-Phenylpropionic acid 
• 4842-49-3 (R)-2-(4-methoxyphenyl)propionic acid 
• 13448-81-2 (S)-methyl atrolactate 
• 13448-80-1 methyl R-(-)-atrolactate 
• 20731-95-7 methyl 2-hydroxy-2-phenylpropanoate 
• 84892-13-7 methyl 2-bromo-2-phenylpropanoate 
• 115420-22-9 2-phenyl-2-<4'-(methylcarbomethoxymethyl)phenyl>propanoate 
• 98475-02-6 dimethyl 2,3-dimethyl-2,3-diphenylsuccinate 

Relevant articles and documents

Continuous in situ electrogenaration of a 2-pyrrolidone anion in a microreactor: application to highly efficient monoalkylation of methyl phenylacetate

We have successfully demonstrated effective generation of an electrogenerated base (EGB) such as the 2-pyrrolidone anion and its rapid use for the following alkylation reaction in a flow microreactor system without the need for severe reaction conditions. The key feature of the method is effective and selective preparation of monoalkylated products.

Palladium-Catalyzed Asymmetric Hydroesterification of α-Aryl Acrylic Acids to Chiral Substituted Succinates

A palladium-catalyzed asymmetric hydroesterification of α-aryl acrylic acids with CO and alcohol was developed, preparing a variety of chiral α-substituted succinates in moderate yields with high ee values. The kinetic profile of the reaction progress revealed that the alkene substrate first underwent the hydroesterification followed by esterification with alcohol. The origin of the enantioselectivity was elucidated by density functional theory computation.

PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation

A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired products.