2251-54-9 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule of the compound.
2. Derivative of benzenedicarboxylic acid (phthalic acid)
Explanation
1,2-Benzenedicarboxylic acid, 3,4,6-trifluorois derived from benzenedicarboxylic acid by substituting three hydrogen atoms on the benzene ring with fluorine atoms.
Explanation
The three fluorine atoms are attached to the 3rd, 4th, and 6th positions of the benzene ring, which differentiates it from other isomers of fluorinated benzenedicarboxylic acids.
Explanation
The compound is used as a starting material in the production of different industrial chemicals and polymers, such as those used in plastics, resins, and adhesives.
5. Pharmaceutical and agrochemical synthesis
Explanation
1,2-Benzenedicarboxylic acid, 3,4,6-trifluorois also utilized in the synthesis of pharmaceuticals and agrochemicals due to its unique properties.
Explanation
The presence of fluorine atoms in the structure of the compound provides it with unique properties, such as increased stability and reactivity, making it valuable in a wide range of applications.
Explanation
Due to potential health and environmental risks associated with the compound, it is crucial to handle and dispose of it properly to minimize any negative impacts.
Explanation
The compound consists of an aromatic benzene ring with three fluorine atoms and two carboxyl groups (-COOH) attached to the 1st and 2nd carbon atoms.
Fluorine substitution
3, 4, and 6 positions on the benzene ring
Industrial applications
Building block for various chemicals and polymers
Unique properties
Presence of fluorine atoms
Health and environmental risks
Proper handling and disposal required
Chemical structure
Aromatic ring with fluorine and carboxyl groups
Check Digit Verification of cas no
The CAS Registry Mumber 2251-54-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,5 and 1 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2251-54:
(6*2)+(5*2)+(4*5)+(3*1)+(2*5)+(1*4)=59
59 % 10 = 9
So 2251-54-9 is a valid CAS Registry Number.
2251-54-9Relevant articles and documents
Process improvements in the synthesis of 2,4,5-trifluorobenzoic acid. selective hydrodefluorination of tetrafluorophthalimides
Fertel, Lawrence B.
, p. 111 - 115 (2013/09/08)
An improved preparation of the fluoroquinolone antibacterial intermediate 2,4,5-trifluorobenzoic acid is described. A combination of a selective hydrodefluorination and hydrolysis reaction of 3,4,5,6-tetrafluoro-N-methylphthalimide leading to 3,5,6-trifluorophthalic acid was key to the success of the process. In addition the development of a two-step, one-pot imidization/ halogen exchange from tetrachlorophthalic anhydride to 3,4,5,6-tetrafluoro-N-methylphthalimide in sulfolane solvent is detailed.
Preparation of 3,4,6-trifluorophthalic acid
-
, (2008/06/13)
3,4,6-trifluorophthalic acid is prepared in high yield by reaction of a 3,4,6-trichloro-N-substituted phthalimide with potassium fluoride at temperatures in the range of 200° to 270° C. in the absence of a catalyst to form the corresponding trifluoro-N-su
Tetrafluoro-N-phenylphthalimide
-
, (2008/06/13)
Chlorinated phthalic anhydrides are converted to fluorinated phthalic acids without dilactone formation by reacting an anhydride with a primary amine under anhydrous conditions to form the corresponding chlorinated-N-substituted phthalimide which in turn is reacted with a fluorinating agent under anhydrous conditions to form the corresponding fluorinated phthalimide which is hydrolyzed to form the corresponding fluorinated phthalic acid. In a preferred embodiment tetrachlorophthalic anhydride is refluxed with aniline in the presence of glacial acetic acid for 5 to 10 hours to form tetrachloro-N-phenylphthalimide which is reacted with KF in sulfolane in the presence of tributylhexadecylophosphonium bromide under nitrogen at 140° C. to 160° C. for 10 to 15 hours to form tetrafluoro-N-phenylphthalimide which in turn is hydrolyzed by refluxing with 50% H2 SO4 for 15 to 25 hours. The tetrafluoro-N-phenylphthalimide is a novel compound. The fluorinated phthalic acid products are intermediates for the corresponding fluorinated phthalic anhydrides, fluorinated benzoic acids and fluorinated benzenes.
