226881-07-8 Usage
Description
1-(4-Bromophenyl)-2-oxopyrrolidine-3-carboxylic acid is a chemical compound with a molecular formula C11H10BrNO3. It is a derivative of pyrrolidine with a carboxylic acid group and a bromophenyl substituent. 1-(4-Bromophenyl)-2-oxopyrrolidine-3-carboxylic acid is often used in research and pharmaceutical development due to its potential biological and pharmacological properties. It can act as a precursor or intermediate for the synthesis of various drugs and compounds. Its specific uses and applications can vary depending on the research or industry in which it is being utilized.
Uses
Used in Pharmaceutical Development:
1-(4-Bromophenyl)-2-oxopyrrolidine-3-carboxylic acid is used as a precursor or intermediate for the synthesis of various drugs and compounds. Its unique structure and functional groups make it a valuable component in the development of new pharmaceuticals with potential therapeutic applications.
Used in Research:
1-(4-Bromophenyl)-2-oxopyrrolidine-3-carboxylic acid is used as a research compound to study its biological and pharmacological properties. Researchers can use this compound to investigate its potential interactions with biological targets and its effects on various biological processes, which can lead to the discovery of new therapeutic agents or a better understanding of disease mechanisms.
Used in Chemical Synthesis:
1-(4-Bromophenyl)-2-oxopyrrolidine-3-carboxylic acid is used as a building block in the synthesis of more complex organic compounds. Its carboxylic acid and bromophenyl substituent groups can be utilized in various chemical reactions to form a wide range of molecules with different properties and applications.
Used in Drug Discovery:
1-(4-Bromophenyl)-2-oxopyrrolidine-3-carboxylic acid is used as a starting material in drug discovery efforts. Its unique structure and functional groups can be modified to create new compounds with potential therapeutic effects. 1-(4-Bromophenyl)-2-oxopyrrolidine-3-carboxylic acid can be a valuable asset in the search for new drugs to treat various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 226881-07-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,8,8 and 1 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 226881-07:
(8*2)+(7*2)+(6*6)+(5*8)+(4*8)+(3*1)+(2*0)+(1*7)=148
148 % 10 = 8
So 226881-07-8 is a valid CAS Registry Number.
226881-07-8Relevant articles and documents
Discovery of novel dual c-Met/HDAC inhibitors as a promising strategy for cancer therapy
Chen, Fei,Dong, Yuhong,Gong, Ping,Hu, Hao,Liu, Yajing
, (2020/06/01)
Owing to the low efficacy and acquired resistance in clinical trials of c-Met inhibitors, based on the synergistic effects between c-Met and HDAC, novel c-Met and HDAC dual inhibitors were designed and synthesized. We introduced 2-pyrrolidinone to form the 5-atoms linker for c-Met inhibitor and hydroxamic acid as a zinc binding motif for HDAC inhibitor. The highly active dual inhibitor 15f showed excellent and balanced activity against both c-Met (IC50 = 12.50 nM) and HDAC1 (IC50 = 26.97 nM). In those tested tumor cell lines, 15f exhibits efficient antiproliferative activity with greater potency than Vorinostat (SAHA) and Cabozantinib (XL184). However, by comparing with an equimolar mixture of SAHA and Foretinib, we did not observe the compounds showed clearly synergistic antiproliferative effect. Nevertheless, compound 15f was found to induce apoptosis and cause cell cycle arrest in G2/M phase. This proof-of-concept study provides an efficient strategy for discovery of multitarget antitumor drugs.
Method for production of pyrrolidinone derivatives
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, (2008/06/13)
A compound represented by the following formula (12) useful as an intermediate for production of drug or agricultural chemical: (wherein R21to R25are each independently a hydrogen atom, a hydroxyl group, a halogen atom, an alkyl grou
