22766-68-3Relevant articles and documents
A More Sustainable Process for Preparation of the Muscarinic Acetylcholine Antagonist Umeclidinium Bromide
Espadinha, Margarida,Louren?o, Nuno M. T.,Sobral, Luis,Antunes, Rafael,Santos, Maria M. M.
, p. 2053 - 2056 (2018)
A more sustainable process for the synthesis of the long-acting muscarinic acetylcholine antagonist umeclidinium bromide is described. Specifically, we report the synthesis of ethyl 1-(2-chloroethyl)-4-piperidinecarboxylate, a key intermediate in the prep
Method for synthesizing intermediate of high-purity Umeclidinium bromide
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Paragraph 0054; 0058-0060, (2020/08/18)
The invention discloses a method for synthesizing intermediates 1-(2-chloroethyl) piperidine-4-formate and quinuclidin-4-carboxylic ester of Umeclidinium bromide, and particularly discloses a method for synthesizing an intermediate 1-(2-chloroethyl) piperidine-4-formate and quinuclidin-4-carboxylic ester of Umeclidinium bromide. According to the method, crude products of the intermediates 1-(2-chloroethyl) piperidine-4-formate and quinuclidin-4-carboxylate are purified in a molecular distillation or reduced pressure distillation mode, and the high-purity medical intermediates are obtained. Thepurification cost can be effectively reduced through molecular distillation or vacuum distillation, the yield is improved, and the product purity can reach 99% or above. According to the present invention, with the synthesis method, the 1-(2-chloroethyl) piperidine-4-formate and the quinuclidin-4-carboxylate are prepared, the process route is short, the amplified production is easy, and the yieldis high. The method has the characteristics of novel process, high yield, low cost, high product purity and the like.
Halogen-Bonded Supramolecular Capsules in the Solid State, in Solution, and in the Gas Phase
Dumele, Oliver,Schreib, Benedikt,Warzok, Ulrike,Trapp, Nils,Schalley, Christoph A.,Diederich, Fran?ois
supporting information, p. 1152 - 1157 (2017/01/18)
Supramolecular capsules were assembled by neutral halogen bonding (XB) and studied in the solid state, in solution, and in the gas phase. The geometry of the highly organized capsules is shown by an X-ray crystal structure which features the assembly of t