55022-91-8

Basic information

• Product Name: quinuclidine-4-carbaldehyde
• Synonyms: quinuclidine-4-carbaldehyde;1-Azabicyclo[2.2.2]octane-4-carboxaldehyde;4-Quinuclidinecarboxaldehyde
• CAS NO: 55022-91-8
• Molecular Formula: C₈H₁₃NO
• Molecular Weight: 139.19492
• Mol File: 55022-91-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 200℃
• Flash Point: 68℃
• Appearance: /
• Density: 1.08
• CAS DataBase Reference: quinuclidine-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: quinuclidine-4-carbaldehyde(55022-91-8)
• EPA Substance Registry System: quinuclidine-4-carbaldehyde(55022-91-8)

Safety Data

• Hazardous Substances Data: 55022-91-8(Hazardous Substances Data)

Usage

General Description

Quinuclidine-4-carbaldehyde is a chemical compound with the molecular formula C8H13NO. It is a colorless liquid with a pungent odor and is commonly used as a reagent in organic synthesis. It is a quinuclidine derivative and is an important building block in the production of pharmaceuticals and agrochemicals. Quinuclidine-4-carbaldehyde has diverse applications, including as an intermediate in the synthesis of antimalarial drugs and as a catalyst in various organic reactions. Its use in the pharmaceutical industry highlights its importance as a key component in the synthesis of many life-saving medications and therapeutic compounds.

Upstream product

• 22766-68-3 azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester 
• 869112-14-1 1-(2-chloroethyl)-4-piperidinecarboxylic acid ethyl ester 
• 1126-09-6 4-carbethoxypiperidine 
• 26458-78-6 4-cyanoquinuclidine 
• 26608-58-2 4-hydroxymethylquinuclidine 

Downstream Products

• 1006602-20-5 C₁₆H₂₀N₂O₃ 
• 52547-86-1 4-ethynylquinuclidine 
• 1609072-64-1 C₃₂H₃₄ClN₃O₅ 
• 1609072-58-3 C₃₂H₃₅N₃O₅ 
• 1609072-55-0 C₃₂H₃₅N₃O₆ 
• 1609072-36-7 C₃₂H₃₄ClN₃O₆ 
• 1609072-37-8 C₃₂H₃₄ClN₃O₆ 
• 1609072-34-5 C₃₂H₃₄ClN₃O₅ 

Relevant articles and documents

6. A Reexamination of Inductive Substituent Constants Derived from pKa Values of 4-Substituted Quinuclidines. Polar Effects. Part VIII

pKa Values of 42 quinuclidinium perchlorates I have been measured in 0.1M aqueous KCl-solution.In a few cases small corrections of earlier thermodynamic pKa values are indicated.These measurements, in conjuction with recent X-ray structure determinations, confirm the reliability of the inductive substituent constants ?qI derived from them.

PROGRANULIN MODULATORS AND METHODS OF USING THE SAME

Provided herein are compounds of formula (I) that modulate progranulin and methods of using the compounds in progranulin- associated disorders, such as Frontotemperal lobe dementia (FTLD).

2 - Substituted cephem compound-containing pharmaceutical composition

PROBLEM TO BE SOLVED: To provide a cephem compound which has a strong antimicrobial activity, in particular effective against various β-lactamase producing Gram negative bacteria, and a composition comprising the compound.SOLUTION: The present invention provides a pharmaceutical composition comprising a compound represented by formula (I), an ester at a carboxyl group, an amino-protected compound when the amino is present on a ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.