228399-00-6Relevant articles and documents
Synthesis and biological evaluation of two novel 2′-substituted tiazofurin analogues
Popsavin, Mirjana,Torovi?, Ljilja,Koji?, Vesna,Bogdanovi?, Gordana,Popsavin, Velimir
, p. 7125 - 7128 (2007/10/03)
Two novel tiazofurin analogues, 2-(2-benzamido-2-deoxy-β-d- ribofuranosyl)thiazole-4-carboxamide 4 and 2-(2-azido-2-deoxy-β-d- ribofuranosyl)thiazole-4-carboxamide 5, have been synthesized starting from d-glucose and evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.
Stereospecific synthesis of two novel cytotoxic pyrazole C-nucleosides from D-glucose
Popsavin, Mirjana,Torovic, Ljilja,Spaic, Sa?a,Stankov, Srdjan,Popsavin, Velimir
, p. 5737 - 5740 (2007/10/03)
A multistep stereospecific synthesis of two novel pyrazole C-nucleosides 12 and 21 has been achieved starting from D-glucose, by utilizing the 2,5- anhydro-D-glucose ethylene acetal derivative 1 as a divergent intermediate. The C-nucleoside 12 was shown to be a moderate inhibitor of the in vitro growth of N2a and BHK 21 tumor cell lines, whereas 21 showed a moderate cytotoxic activity only against N2a cells. (C) 2000 Published by Elsevier Science Ltd.