60084-12-0Relevant articles and documents
Synthesis of highly cytotoxic tiazofurin mimics bearing a 2,3-anhydro function in the furanose ring
Popsavin, Mirjana,Spai?, Sa?a,Svir?ev, Milo?,Koji?, Vesna,Bogdanovi?, Gordana,Pejanovi?, Vjera,Popsavin, Velimir
experimental part, p. 7637 - 7645 (2009/12/06)
This paper describes a divergent de novo synthesis of 2-(2,3-anhydro-β-d-ribofuranosyl)thiazole-4-carboxamide (2′,3′-anhydro-tiazofurin) and the corresponding α- and β-homo-C-nucleosides. The synthetic approach was based on a multistep transformation of d-glucose into suitably protected aldonthioamides followed by their subsequent cyclocondensation with ethyl bromopyruvate to form the thiazole ring. Antiproliferative activity of the target molecules is reported against several human tumour cell lines.
Synthesis and biological evaluation of two novel 2′-substituted tiazofurin analogues
Popsavin, Mirjana,Torovi?, Ljilja,Koji?, Vesna,Bogdanovi?, Gordana,Popsavin, Velimir
, p. 7125 - 7128 (2007/10/03)
Two novel tiazofurin analogues, 2-(2-benzamido-2-deoxy-β-d- ribofuranosyl)thiazole-4-carboxamide 4 and 2-(2-azido-2-deoxy-β-d- ribofuranosyl)thiazole-4-carboxamide 5, have been synthesized starting from d-glucose and evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.
A new synthetic methodology for tiazofurin
Ramasamy, Kanda S.,Bandaru, Rajanikanth,Averett, Devron
, p. 5849 - 5851 (2007/10/03)
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