22849-48-5Relevant articles and documents
Effect of Tertiary Bases on O-Benzotriazolyluronium Salt-Induced Peptide Segment Coupling
Carpino, Louis A.,El-Fahman, Ayman
, p. 695 - 698 (2007/10/02)
Collidine activation of O-(7-azabenzotriazolyl)uronium salts leads to relatively low levels of racemization in the coupling of peptide segments, especially with reagents derived from 1,1-carbonyldipyrrolidine
1-ISOPROPYLALLYLOXYCARBONYL (IPAoc) AS A PROTECTIVE GROUP OF AMINES AND ITS DEPROTECTION CATALYSED BY PALLADIUM-PHOSPHINE COMPLEX
Minami, Ichiro,Yuhara, Masami,Tsuji, Jiro
, p. 2737 - 2740 (2007/10/02)
As a new protective group of amines, 1-isopropylallyloxycarbonyl (IPAoc) group was developed.IPAoc group can be removed by treatment with a palladium-phosphine catalyst forming carbon dioxide and 4-methyl-1,3-pentadiene by the decarboxylation and β-hydrogen elimination of (?-1-isopropylallyl)-palladium intermediate under neutral condititons.The present protection-deprotection was applied to a one-pot peptide synthesis.
Racemization-Free Photochemical Coupling of Peptide Segments
Pass, Sh.,Amit, B.,Patchornik, A.
, p. 7674 - 7675 (2007/10/02)
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